Literature DB >> 17923493

Extensive genetic diversity in the Plasmodium falciparum Na+/H+ exchanger 1 transporter protein implicated in quinine resistance.

Sumiti Vinayak1, Mohammad Tauqeer Alam, Mala Upadhyay, Manoj K Das, Vas Dev, Neeru Singh, Aditya P Dash, Yagya D Sharma.   

Abstract

The Plasmodium falciparum Na(+)/H(+) exchanger (Pfnhe-1) locus at chromosome 13 and another locus at chromosome 9 have recently been proposed to influence quinine resistance. Here, we sequenced the ms4760 locus of the Pfnhe-1 gene from 244 P. falciparum isolates collected from five different regions of India. A total of 16 different ms4760 alleles (with one to five DNNND repeats) were observed among these isolates. Interestingly, areas with a high prevalence of chloroquine and sulfadoxine-pyrimethamine resistance showed more Pfnhe-1 DNNND repeats compared to low drug resistance areas. The extent of genetic diversity at the ms4760 locus also varied from one region to another, with expected heterozygosity values ranging from 0.47 to 0.88.

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Year:  2007        PMID： 17923493      PMCID： PMC2167966          DOI： 10.1128/AAC.00317-07

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  16 in total

1.  DnaSP, DNA polymorphism analyses by the coalescent and other methods.

Authors:  Julio Rozas; Juan C Sánchez-DelBarrio; Xavier Messeguer; Ricardo Rozas
Journal:  Bioinformatics       Date:  2003-12-12       Impact factor: 6.937

Review 2.  Effectiveness of antimalarial drugs.

Authors:  J Kevin Baird
Journal:  N Engl J Med       Date:  2005-04-14       Impact factor: 91.245

3.  Prevalence of mutations associated with higher levels of sulfadoxine-pyrimethamine resistance in Plasmodium falciparum isolates from Car Nicobar Island and Assam, India.

Authors:  Anwar Ahmed; Vanshika Lumb; Manoj K Das; Vas Dev; Yagya D Sharma
Journal:  Antimicrob Agents Chemother       Date:  2006-09-18       Impact factor: 5.191

Review 4.  Transporters involved in resistance to antimalarial drugs.

Authors:  Stephanie G Valderramos; David A Fidock
Journal:  Trends Pharmacol Sci       Date:  2006-09-25       Impact factor: 14.819

Review 5.  Drug-resistant malaria.

Authors:  John E Hyde
Journal:  Trends Parasitol       Date:  2005-09-02

6.  Quadruple mutations in dihydrofolate reductase of Plasmodium falciparum isolates from Car Nicobar Island, India.

Authors:  Anwar Ahmed; Manoj K Das; Vas Dev; Muheet A Saifi; Yagya D Sharma
Journal:  Antimicrob Agents Chemother       Date:  2006-04       Impact factor: 5.191

7.  Progressive increase in point mutations associated with chloroquine resistance in Plasmodium falciparum isolates from India.

Authors:  Pooja Mittra; Sumiti Vinayak; Hina Chandawat; Manoj K Das; Neeru Singh; Sukla Biswas; Vas Dev; Ashwani Kumar; Musharraf A Ansari; Yagya D Sharma
Journal:  J Infect Dis       Date:  2006-03-21       Impact factor: 5.226

8.  Dissecting the loci of low-level quinine resistance in malaria parasites.

Authors:  Michael T Ferdig; Roland A Cooper; Jianbing Mu; Bingbing Deng; Deirdre A Joy; Xin-zhuan Su; Thomas E Wellems
Journal:  Mol Microbiol       Date:  2004-05       Impact factor: 3.501

9.  Wide variation in microsatellite sequences within each Pfcrt mutant haplotype.

Authors:  Sumiti Vinayak; Pooja Mittra; Yagya D Sharma
Journal:  Mol Biochem Parasitol       Date:  2006-02-21       Impact factor: 1.759

10.  Sequence of Plasmodium falciparum chromosomes 2, 10, 11 and 14.

Authors:  Malcolm J Gardner; Shamira J Shallom; Jane M Carlton; Steven L Salzberg; Vishvanath Nene; Azadeh Shoaibi; Anne Ciecko; Jeffery Lynn; Michael Rizzo; Bruce Weaver; Behnam Jarrahi; Michael Brenner; Babak Parvizi; Luke Tallon; Azita Moazzez; David Granger; Claire Fujii; Cheryl Hansen; James Pederson; Tamara Feldblyum; Jeremy Peterson; Bernard Suh; Sam Angiuoli; Mihaela Pertea; Jonathan Allen; Jeremy Selengut; Owen White; Leda M Cummings; Hamilton O Smith; Mark D Adams; J Craig Venter; Daniel J Carucci; Stephen L Hoffman; Claire M Fraser
Journal:  Nature       Date:  2002-10-03       Impact factor: 49.962
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  13 in total

1.  Differential association of Plasmodium falciparum Na+/H+ exchanger polymorphism and quinine responses in field- and culture-adapted isolates of Plasmodium falciparum.

Authors:  Stéphane Pelleau; Lionel Bertaux; Sébastien Briolant; Michael T Ferdig; Véronique Sinou; Bruno Pradines; Daniel Parzy; Ronan Jambou
Journal:  Antimicrob Agents Chemother       Date:  2011-09-26       Impact factor: 5.191

2.  Limited ability of Plasmodium falciparum pfcrt, pfmdr1, and pfnhe1 polymorphisms to predict quinine in vitro sensitivity or clinical effectiveness in Uganda.

Authors:  Frederick N Baliraine; Samuel L Nsobya; Jane Achan; James K Tibenderana; Ambrose O Talisuna; Bryan Greenhouse; Philip J Rosenthal
Journal:  Antimicrob Agents Chemother       Date:  2010-11-15       Impact factor: 5.191

3.  In vitro sensitivity of Plasmodium falciparum clinical isolates from the China-Myanmar border area to quinine and association with polymorphism in the Na+/H+ exchanger.

Authors:  Hao Meng; Rongping Zhang; Henglin Yang; Qi Fan; Xinzhuan Su; Jun Miao; Liwang Cui; Zhaoqing Yang
Journal:  Antimicrob Agents Chemother       Date:  2010-07-19       Impact factor: 5.191

4.  Plasmodium falciparum Na+/H+ exchanger (pfnhe-1) genetic polymorphism in Indian Ocean malaria-endemic areas.

Authors:  Valérie Andriantsoanirina; Nimol Khim; Arsene Ratsimbasoa; Benoit Witkowski; Christophe Benedet; Lydie Canier; Christiane Bouchier; Magali Tichit; Rémy Durand; Didier Ménard
Journal:  Am J Trop Med Hyg       Date:  2012-12-03       Impact factor: 2.345

5.  Association of microsatellite variations of Plasmodium falciparum Na+/H+ exchanger (Pfnhe-1) gene with reduced in vitro susceptibility to quinine: lack of confirmation in clinical isolates from Africa.

Authors:  Valérie Andriantsoanirina; Didier Ménard; Stéphane Rabearimanana; Véronique Hubert; Christiane Bouchier; Magali Tichit; Jacques Le Bras; Rémy Durand
Journal:  Am J Trop Med Hyg       Date:  2010-05       Impact factor: 2.345

Review 6.  Global analysis of Plasmodium falciparum Na(+)/H(+) exchanger (pfnhe-1) allele polymorphism and its usefulness as a marker of in vitro resistance to quinine.

Authors:  Didier Ménard; Valérie Andriantsoanirina; Nimol Khim; Arsène Ratsimbasoa; Benoit Witkowski; Christophe Benedet; Lydie Canier; Odile Mercereau-Puijalon; Rémy Durand
Journal:  Int J Parasitol Drugs Drug Resist       Date:  2012-10-26       Impact factor: 4.077

7.  Quinine treatment selects the pfnhe-1 ms4760-1 polymorphism in Malian patients with Falciparum malaria.

Authors:  Aminatou Kone; Jianbing Mu; Hamma Maiga; Abdoul H Beavogui; Omar Yattara; Issaka Sagara; Mamadou M Tekete; Oumar B Traore; Antoine Dara; Souleymane Dama; Nouhoum Diallo; Aly Kodio; Aliou Traoré; Anders Björkman; Jose P Gil; Ogobara K Doumbo; Thomas E Wellems; Abdoulaye A Djimde
Journal:  J Infect Dis       Date:  2012-11-16       Impact factor: 5.226

8.  In vitro activities of quinine and other antimalarials and pfnhe polymorphisms in Plasmodium isolates from Kenya.

Authors:  John Okombo; Steven M Kiara; Josea Rono; Leah Mwai; Lewa Pole; Eric Ohuma; Steffen Borrmann; Lynette Isabella Ochola; Alexis Nzila
Journal:  Antimicrob Agents Chemother       Date:  2010-06-01       Impact factor: 5.191

9.  Plasmodium falciparum Na+/H+ exchanger 1 transporter is involved in reduced susceptibility to quinine.

Authors:  Maud Henry; Sébastien Briolant; Agnès Zettor; Stéphane Pelleau; Meili Baragatti; Eric Baret; Joel Mosnier; Rémy Amalvict; Thierry Fusai; Christophe Rogier; Bruno Pradines
Journal:  Antimicrob Agents Chemother       Date:  2009-03-09       Impact factor: 5.191

10.  Probing the multifactorial basis of Plasmodium falciparum quinine resistance: evidence for a strain-specific contribution of the sodium-proton exchanger PfNHE.

Authors:  Louis J Nkrumah; Paul M Riegelhaupt; Pedro Moura; David J Johnson; Jigar Patel; Karen Hayton; Michael T Ferdig; Thomas E Wellems; Myles H Akabas; David A Fidock
Journal:  Mol Biochem Parasitol       Date:  2009-01-30       Impact factor: 1.759
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