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Literature DB >> 17923079

Retrovirus silencing by an epigenetic TRIM.

James Ellis¹, Akitsu Hotta, Mojgan Rastegar.

Abstract

Embryonic cells silence transcription by retroviruses, but how do they recognize virus DNA? In this issue, Wolf and Goff (2007) report that a TRIM28 corepressor complex binds to the retrovirus primer binding site. Epigenetic silencing of retrovirus transcription is accomplished by "writing" a dimethyl mark on lysine 9 of histone H3 that is read by the heterochromatin protein HP1gamma.

Entities: Chemical Gene

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Year: 2007 PMID： 17923079 DOI： 10.1016/j.cell.2007.09.029

Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582

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Cited

14 in total

Review 1. TRIMmunity: the roles of the TRIM E3-ubiquitin ligase family in innate antiviral immunity.

Authors: Ricardo Rajsbaum; Adolfo García-Sastre; Gijs A Versteeg
Journal: J Mol Biol Date: 2013-12-12 Impact factor: 5.469

2. Streamlined platform for short hairpin RNA interference and transgenesis in cultured mammalian cells.

Authors: Piyush Khandelia; Karen Yap; Eugene V Makeyev
Journal: Proc Natl Acad Sci U S A Date: 2011-07-18 Impact factor: 11.205

Review 3. Transcriptional Regulation of Brain-Derived Neurotrophic Factor (BDNF) by Methyl CpG Binding Protein 2 (MeCP2): a Novel Mechanism for Re-Myelination and/or Myelin Repair Involved in the Treatment of Multiple Sclerosis (MS).

Authors: Tina KhorshidAhmad; Crystal Acosta; Claudia Cortes; Ted M Lakowski; Surendiran Gangadaran; Michael Namaka
Journal: Mol Neurobiol Date: 2015-01-13 Impact factor: 5.590

Retrovirus silencing by an epigenetic TRIM.

Review 1. TRIMmunity: the roles of the TRIM E3-ubiquitin ligase family in innate antiviral immunity.

2. Streamlined platform for short hairpin RNA interference and transgenesis in cultured mammalian cells.

Review 3. Transcriptional Regulation of Brain-Derived Neurotrophic Factor (BDNF) by Methyl CpG Binding Protein 2 (MeCP2): a Novel Mechanism for Re-Myelination and/or Myelin Repair Involved in the Treatment of Multiple Sclerosis (MS).

4. Retroviral DNA methylation and epigenetic repression are mediated by the antiviral host protein Daxx.

5. Global protein phosphorylation dynamics during deoxynivalenol-induced ribotoxic stress response in the macrophage.

6. Toolkit for evaluating genes required for proliferation and survival using tetracycline-regulated RNAi.

7. The genetic and epigenetic journey of embryonic stem cells into mature neural cells.

8. TRIM28 represses transcription of endogenous retroviruses in neural progenitor cells.

9. MECP2 isoform-specific vectors with regulated expression for Rett syndrome gene therapy.

10. TRIM59, a novel multiple cancer biomarker for immunohistochemical detection of tumorigenesis.