Andrew L Folpe1, Kumarasen Cooper. 1. Division of Anatomic Pathology, Mayo Clinic, 200 1st St SW, Rochester, MN 55905, USA. Folpe.Andrew@Mayo.edu
Abstract
CONTEXT: Pleomorphic cutaneous spindle cell tumors can be difficult to distinguish solely on histologic grounds. The use of ancillary immunohistochemical studies can greatly assist in this differential diagnosis. OBJECTIVE: To review histologic and immunohistochemical aspects of cutaneous spindle cell tumors and discuss a basic panel of markers to assist in the differential diagnosis. DATA SOURCES: English-language literature published between 1981 and 2005. CONCLUSIONS: A basic immunohistochemistry panel for high-molecular-weight cytokeratin, melanocytic markers (S100 protein, HMB-45, Melan-A), smooth muscle actin, desmin, and endothelial markers (CD31, CD34) is effective in diagnosing most cutaneous spindle cell tumors.
CONTEXT: Pleomorphic cutaneous spindle cell tumors can be difficult to distinguish solely on histologic grounds. The use of ancillary immunohistochemical studies can greatly assist in this differential diagnosis. OBJECTIVE: To review histologic and immunohistochemical aspects of cutaneous spindle cell tumors and discuss a basic panel of markers to assist in the differential diagnosis. DATA SOURCES: English-language literature published between 1981 and 2005. CONCLUSIONS: A basic immunohistochemistry panel for high-molecular-weight cytokeratin, melanocytic markers (S100 protein, HMB-45, Melan-A), smooth muscle actin, desmin, and endothelial markers (CD31, CD34) is effective in diagnosing most cutaneous spindle cell tumors.
Authors: Richard Nuccitelli; Xinhua Chen; Andrei G Pakhomov; Wallace H Baldwin; Saleh Sheikh; Jennifer L Pomicter; Wei Ren; Christopher Osgood; R James Swanson; Juergen F Kolb; Stephen J Beebe; Karl H Schoenbach Journal: Int J Cancer Date: 2009-07-15 Impact factor: 7.396