| Literature DB >> 17922175 |
Yi Fu1, Jian Zhang, Joseph R Lakowicz.
Abstract
In this short paper, we reported the enhanced fluorescence from a single fluorophore bound to a 50nm silver nanoparticle. We found that on average the Cy5 molecules bound to metal nanoparticles are approximately 15-fold brighter than that of free dyes, and that single molecule lifetimes are shorter as compared to free fluorophores. The increased emission rate is primarily the result of local plasmon enhancement. These results demonstrate that the use of fluorophore-metal interactions can increase the brightness and photostability of fluorophores for single molecule detection.Entities:
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Year: 2007 PMID: 17922175 PMCID: PMC2763915 DOI: 10.1007/s10895-007-0259-0
Source DB: PubMed Journal: J Fluoresc ISSN: 1053-0509 Impact factor: 2.217