Literature DB >> 17918856

Nitric oxide prodrugs: diazeniumdiolate anions of hindered secondary amines.

Harinath Chakrapani1, Brett M Showalter, Michael L Citro, Larry K Keefer, Joseph E Saavedra.   

Abstract

Nitric oxide prodrugs derived from hindered secondary amines were prepared. The decomposition patterns of these prodrugs indicate that alpha-methyl groups around the nitrogen bearing the diazeniumdiolate group prolong their half-life in aqueous buffer.

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Year:  2007        PMID： 17918856     DOI： 10.1021/ol7019636

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  3 in total

1.  Synthesis and in vitro anti-leukemic activity of structural analogues of JS-K, an anti-cancer lead compound.

Authors:  Harinath Chakrapani; Michael M Goodblatt; Vidya Udupi; Swati Malaviya; Paul J Shami; Larry K Keefer; Joseph E Saavedra
Journal:  Bioorg Med Chem Lett       Date:  2008-01-04       Impact factor: 2.823

2.  Decoding nitric oxide release rates of amine-based diazeniumdiolates.

Authors:  Yan-Ni Wang; Jack Collins; Ryan J Holland; Larry K Keefer; Joseph Ivanic
Journal:  J Phys Chem A       Date:  2013-07-23       Impact factor: 2.781

3.  Aryl bis(diazeniumdiolates): potent inducers of S-glutathionylation of cellular proteins and their in vitro antiproliferative activities.

Authors:  Daniela Andrei; Anna E Maciag; Harinath Chakrapani; Michael L Citro; Larry K Keefer; Joseph E Saavedra
Journal:  J Med Chem       Date:  2008-12-25       Impact factor: 7.446
  3 in total

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