Literature DB >> 17917790

The special location of p-H3 and p-CENP-A on heterochromatin during mitosis in MCF-7.

Dengwen Li1, Ruming Liu, Liping Song, Hao Zhou, Jiatong Chen, Xitai Huang.   

Abstract

CENP-A locates at nucleosome as histone H3-like proteins, and is phosphorylated during mitosis. We investigated the dynamic distribution of p-CENP-A to explore the details of its function. We found that p-CENP-A was phosphorylated at late prophase, and the signal of p-CENP-A arranged at equatorial plate along with nucleosomes at metaphase, but moved to midbody at later phase of mitosis. The phosphorylation modification of CENP-A shares some characters of H3, but has different temporal patterns during mitosis. Our results suggested that the CENP-A might have similar functions as H3, but with different patterns for their different binging materials.

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Year:  2007        PMID： 17917790     DOI： 10.1007/s11033-007-9136-9

Source DB:  PubMed          Journal:  Mol Biol Rep        ISSN： 0301-4851            Impact factor:   2.316


  16 in total

Review 1.  Phosphorylation of histone and histone-like proteins by aurora kinases during mitosis.

Authors:  Gaetan Pascreau; Yannick Arlot-Bonnemains; Claude Prigent
Journal:  Prog Cell Cycle Res       Date:  2003

2.  Dissection of the mammalian midbody proteome reveals conserved cytokinesis mechanisms.

Authors:  Ahna R Skop; Hongbin Liu; John Yates; Barbara J Meyer; Rebecca Heald
Journal:  Science       Date:  2004-05-27       Impact factor: 47.728

3.  Centromeric chromatin exhibits a histone modification pattern that is distinct from both euchromatin and heterochromatin.

Authors:  Beth A Sullivan; Gary H Karpen
Journal:  Nat Struct Mol Biol       Date:  2004-10-10       Impact factor: 15.369

4.  CENP-A is required for accurate chromosome segregation and sustained kinetochore association of BubR1.

Authors:  Vinciane Régnier; Paola Vagnarelli; Tatsuo Fukagawa; Tatiana Zerjal; Elizabeth Burns; Didier Trouche; William Earnshaw; William Brown
Journal:  Mol Cell Biol       Date:  2005-05       Impact factor: 4.272

5.  The Drosophila melanogaster condensin subunit Cap-G interacts with the centromere-specific histone H3 variant CID.

Authors:  Hubert Jäger; Melanie Rauch; Stefan Heidmann
Journal:  Chromosoma       Date:  2004-12-09       Impact factor: 4.316

6.  Differential role of CENP-A in the segregation of holocentric C. elegans chromosomes during meiosis and mitosis.

Authors:  Joost Monen; Paul S Maddox; Francie Hyndman; Karen Oegema; Arshad Desai
Journal:  Nat Cell Biol       Date:  2005-11-06       Impact factor: 28.824

7.  The N terminus of the centromere H3-like protein Cse4p performs an essential function distinct from that of the histone fold domain.

Authors:  Y Chen; R E Baker; K C Keith; K Harris; S Stoler; M Fitzgerald-Hayes
Journal:  Mol Cell Biol       Date:  2000-09       Impact factor: 4.272

8.  Human centromere protein A (CENP-A) can replace histone H3 in nucleosome reconstitution in vitro.

Authors:  K Yoda; S Ando; S Morishita; K Houmura; K Hashimoto; K Takeyasu; T Okazaki
Journal:  Proc Natl Acad Sci U S A       Date:  2000-06-20       Impact factor: 11.205

9.  A mutation in CSE4, an essential gene encoding a novel chromatin-associated protein in yeast, causes chromosome nondisjunction and cell cycle arrest at mitosis.

Authors:  S Stoler; K C Keith; K E Curnick; M Fitzgerald-Hayes
Journal:  Genes Dev       Date:  1995-03-01       Impact factor: 11.361

10.  CENP-A is phosphorylated by Aurora B kinase and plays an unexpected role in completion of cytokinesis.

Authors:  S G Zeitlin; R D Shelby; K F Sullivan
Journal:  J Cell Biol       Date:  2001-12-24       Impact factor: 10.539
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