| Literature DB >> 17917275 |
Mai Efdi1, Kenji Ohguchi, Yukihiro Akao, Yoshinori Nozawa, Mamoru Koketsu, Hideharu Ishihara.
Abstract
In this study, we examined the effect of N-trans-feruloyltyramine (FA) on melanogenesis in mouse B16 melanoma cells. Melanogenesis was inhibited by FA in a dose-dependent manner. FA exhibited a greater potency than kojic acid as a standard inhibitor of melanogenesis. Moreover, treatment of B16 melanoma cells with FA was found to cause marked decreases in the expression levels of tyrosinase. FA-induced downregulation of tyrosinase resulted in suppression of melanin biosynthesis in murine B16 melanoma cells.Entities:
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Year: 2007 PMID: 17917275 DOI: 10.1248/bpb.30.1972
Source DB: PubMed Journal: Biol Pharm Bull ISSN: 0918-6158 Impact factor: 2.233