Literature DB >> 17917039

Th1 or Th2 balance regulated by interaction between dendritic cells and NKT cells.

Kazunori Onoé1, Yoshiki Yanagawa, Keita Minami, Norifumi Iijima, Kazuya Iwabuchi.   

Abstract

If Th1 or Th2 polarization could be artificially manipulated, effective immune responses would be generated depending on nature of the targets. In this study we attempted to regulate CD40 expressions on dendritic cells (DCs) in order to modify the T cell response. It was found that reducing agents selectively inhibited surface expression of CD40 on DCs. This finding may provide a new strategy of DC-mediated modulation of the Th1/Th2 balance. It was also shown that NKT-produced Th1/Th2 cytokine balance was under control of negative feedback loop through DCs. Th1 cytokine-pretreated DCs mainly induced Th2 cytokine production, whereas Th2 cytokine-pretreated DCs induced Th1 cytokine production by alpha-galactosylceramide-stimulated NKT cells. The negative feedback regulation system could be applicable to therapeutics of various diseases based on immunological disorders.

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Year:  2007        PMID： 17917039     DOI： 10.1007/s12026-007-0011-5

Source DB:  PubMed          Journal:  Immunol Res        ISSN： 0257-277X            Impact factor:   2.829


  40 in total

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5.  Sequential production of interferon-gamma by NK1.1(+) T cells and natural killer cells is essential for the antimetastatic effect of alpha-galactosylceramide.

Authors:  Mark J Smyth; Nadine Y Crowe; Daniel G Pellicci; Konstantinos Kyparissoudis; Janice M Kelly; Kazuyoshi Takeda; Hideo Yagita; Dale I Godfrey
Journal:  Blood       Date:  2002-02-15       Impact factor: 22.113

6.  Role of early- or late-phase activation of p38 mitogen-activated protein kinase induced by tumour necrosis factor-alpha or 2,4-dinitrochlorobenzene during maturation of murine dendritic cells.

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Review 5.  Type I natural killer T cells: naturally born for fighting.

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Journal:  Acta Pharmacol Sin       Date:  2010-08-09       Impact factor: 6.150

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Review 8.  Combination treatment with progesterone and vitamin D hormone may be more effective than monotherapy for nervous system injury and disease.

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9.  Impaired SLAM-SLAM homotypic interaction between invariant NKT cells and dendritic cells affects differentiation of IL-4/IL-10-secreting NKT2 cells in nonobese diabetic mice.

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10.  Alpha versus beta: are we on the way to resolve the mystery as to which is the endogenous ligand for natural killer T cells?

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Journal:  Clin Exp Immunol       Date:  2009-09-30       Impact factor: 4.330
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