Literature DB >> 17916049

Natural IgM-mediated innate autoimmunity: a new target for early intervention of ischemia-reperfusion injury.

Ming Zhang1, Michael C Carroll.   

Abstract

Recent studies showed that innate autoimmunity is an early mechanism for ischemia-reperfusion (I/R) injury. Results from different animal models showed that reperfusion of ischemic tissues elicits an acute inflammatory response involving a complement system, which is activated by autoreactive natural IgM. Moreover, ischemia-specific self-targets were identified. In contrast to the unsuccessful attempts in the past to treat I/R injury, targeting natural IgM-mediated innate autoimmunity may open a new avenue for early intervention.

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Year:  2007        PMID： 17916049     DOI： 10.1517/14712598.7.10.1575

Source DB:  PubMed          Journal:  Expert Opin Biol Ther        ISSN： 1471-2598            Impact factor:   4.388


  17 in total

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Review 2.  The Role of Damage-Associated Molecular Patterns in Human Diseases: Part I - Promoting inflammation and immunity.

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Journal:  Sultan Qaboos Univ Med J       Date:  2015-01-21

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Authors:  Wen-Chao Song; Garret A FitzGerald
Journal:  J Clin Invest       Date:  2020-08-03       Impact factor: 14.808

Review 5.  Effects of complement activation on allograft injury.

Authors:  Joong Hyuk Sheen; Peter S Heeger
Journal:  Curr Opin Organ Transplant       Date:  2015-08       Impact factor: 2.640

6.  Wiskott-Aldrich syndrome protein (WASP) and N-WASP are critical for peripheral B-cell development and function.

Authors:  Lisa S Westerberg; Carin Dahlberg; Marisa Baptista; Christopher J Moran; Cynthia Detre; Marton Keszei; Michelle A Eston; Frederick W Alt; Cox Terhorst; Luigi D Notarangelo; Scott B Snapper
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7.  Small β2-glycoprotein I peptides protect from intestinal ischemia reperfusion injury.

Authors:  Michael R Pope; Urska Bukovnik; John M Tomich; Sherry D Fleming
Journal:  J Immunol       Date:  2012-10-03       Impact factor: 5.422

8.  Early complement factors in the local tissue immunocomplex generated during intestinal ischemia/reperfusion injury.

Authors:  Haekyung Lee; Danielle J Green; Lawrence Lai; Yunfang Joan Hou; Jens C Jensenius; David Liu; Cheolho Cheong; Chae Gyu Park; Ming Zhang
Journal:  Mol Immunol       Date:  2009-12-09       Impact factor: 4.407

Review 9.  Complement and Transplantation: From New Mechanisms to Potential Biomarkers and Novel Treatment Strategies.

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Review 10.  The Role of Damage-Associated Molecular Patterns (DAMPs) in Human Diseases: Part II: DAMPs as diagnostics, prognostics and therapeutics in clinical medicine.

Authors:  Walter G Land
Journal:  Sultan Qaboos Univ Med J       Date:  2015-05-28
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