Literature DB >> 179144

Increased sarcoma virus RNA in cells transformed by leukemia viruses: model for leukemogenesis.

P T Peebles, E M Scolnick, R S Howk.   

Abstract

A morphologically flat revertant of mink cells nonproductively infected with Moloney sarcoma virus exhibited contact inhibition and lacked detectable sarcoma virus RNA. Superinfection by usually nontransforming type C mammalian leukemia-causing viruses induced transformation and increased sarcoma virus RNA. The results suggest a model for leukemogenesis in animals by increasing, during replication of usually nontransforming leukemia viruses, the levels of RNA from potentially oncogenic cell or integrated virus transforming genes.

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Year:  1976        PMID： 179144     DOI： 10.1126/science.179144

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  5 in total

1.  Quantitation and localization of Rous sarcoma virus-specific RNA in transformed and revertant field vole cells.

Authors:  R A Krzyzek; A F Lau; P K Vogt; A J Faras
Journal:  J Virol       Date:  1978-02       Impact factor: 5.103

2.  Glucocorticoids induce focus formation and increase sarcoma viral expression in a mink cell line that contains a murine sarcoma viral genome.

Authors:  D R Lowy; E M Scolnick
Journal:  J Virol       Date:  1978-01       Impact factor: 5.103

3.  In vitro isolation of stable rat sarcoma viruses.

Authors:  S Rasheed; M B Gardner; R J Huebner
Journal:  Proc Natl Acad Sci U S A       Date:  1978-06       Impact factor: 11.205

4.  Lack of focus formation of S+L- mink cells by the ecotropic murine leukemia viral genome.

Authors:  A Ishimoto
Journal:  J Virol       Date:  1980-10       Impact factor: 5.103

5.  "sarc" sequence transcription in Moloney sarcoma virus-transformed nonproducer cell lines.

Authors:  M Bondurant; R Ramabhadran; M Green; W S Wold
Journal:  J Virol       Date:  1979-01       Impact factor: 5.103
  5 in total

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