| Literature DB >> 17914346 |
Martin R Turner1, Gurjit Chohan, Gerardine Quaghebeur, Richard C D Greenhall, Marios Hadjivassiliou, Kevin Talbot.
Abstract
BACKGROUND: A 44-year-old male presented to a general neurology clinic with a 6-month history of progressive right-sided spastic hemiparesis without sensory symptoms or signs. The thigh muscle in the affected leg showed signs of wasting. The patient had a remote family history of celiac disease. INVESTIGATIONS: Neurological examination, neurophysiological studies, brain MRI scan, routine blood tests, duodenal biopsy, cerebrospinal fluid analysis including polymerase chain reaction test for JC virus DNA, serological testing for HIV and for the presence of serum antibodies to endomysium, gliadin and tissue transglutaminase. DIAGNOSIS: Celiac disease with neurological involvement, mimicking amyotrophic lateral sclerosis. MANAGEMENT: Strict gluten-free diet.Entities:
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Year: 2007 PMID： 17914346 DOI： 10.1038/ncpneuro0631
Source DB: PubMed Journal: Nat Clin Pract Neurol ISSN： 1745-834X