Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Androgen-response elements in hormone-refractory prostate cancer: implications for treatment development.

Literature DB >> 17913662

Androgen-response elements in hormone-refractory prostate cancer: implications for treatment development.

Andrew C Hsieh¹, Eric J Small, Charles J Ryan.

Abstract

Many attempts have been made to derive genetic signatures for progressive prostate cancer for both prognostic and therapeutic purposes. These investigations have resulted in the discovery of many pathways, but the signatures exhibit heterogeneity and restricted reproducibility. A thorough and disciplined analysis of genes with androgen-response elements that are expressed in progressive, castration-resistant prostate cancer is an integral step towards the development of new therapeutic or diagnostic targets. We discuss the effects of bona-fide downstream targets of the androgen receptor on cellular proliferation, evasion of apoptosis, and angiogenesis, and consider the clinical potential of these targets.

Entities: Disease Gene

Mesh：

Substances：

Year: 2007 PMID： 17913662 DOI： 10.1016/S1470-2045(07)70316-9

Source DB: PubMed Journal: Lancet Oncol ISSN： 1470-2045 Impact factor: 41.316

Keyword Cloud
Cited

13 in total

1. Effect of aberrantly methylated androgen receptor target gene PCDH7 on the development of androgen-independent prostate cancer cells.

Authors: Siqi Xu; Xiaoyan Wu; Zhihua Tao; Hongsheng Li; Chenliang Fan; Songjin Chen; Jianwei Guo; Yao Ning; Xuqi Hu
Journal: Genes Genomics Date: 2019-12-23 Impact factor: 1.839

Review 2. Second-line chemotherapy in metastatic docetaxel-resistant prostate cancer: a review.

Authors: Giuseppe Colloca; Antonella Venturino; Franco Checcaglini
Journal: Med Oncol Date: 2011-02-20 Impact factor: 3.064

3. A Hoxb13-driven reverse tetracycline transactivator system for conditional gene expression in the prostate.

Authors: Varsha Rao; Jamie C Heard; Helya Ghaffari; Aminah Wali; Laura N Mutton; Charles J Bieberich
Journal: Prostate Date: 2012-02-01 Impact factor: 4.104

Review 4. Old issues and new perspectives on prostate cancer hormonal therapy: the molecular substratum.

Authors: Leonardo Oliveira Reis
Journal: Med Oncol Date: 2011-05-28 Impact factor: 3.064

5. Noncanonical Wnt signaling mediates androgen-dependent tumor growth in a mouse model of prostate cancer.

Authors: Sayuri Takahashi; Tomoyuki Watanabe; Maiko Okada; Kazuki Inoue; Takashi Ueda; Ichiro Takada; Tetsuro Watabe; Yoko Yamamoto; Toru Fukuda; Takashi Nakamura; Chihiro Akimoto; Tetsuya Fujimura; Maiko Hoshino; Yuuki Imai; Daniel Metzger; Kohei Miyazono; Yasuhiro Minami; Pierre Chambon; Tadaichi Kitamura; Takahiro Matsumoto; Shigeaki Kato
Journal: Proc Natl Acad Sci U S A Date: 2011-03-07 Impact factor: 11.205

10. Chromosome Y variants from different inbred mouse strains are linked to differences in the morphologic and molecular responses of cardiac cells to postpubertal testosterone.

Authors: Bastien Llamas; Ricardo A Verdugo; Gary A Churchill; Christian F Deschepper
Journal: BMC Genomics Date: 2009-04-07 Impact factor: 3.969

Androgen-response elements in hormone-refractory prostate cancer: implications for treatment development.

1. Effect of aberrantly methylated androgen receptor target gene PCDH7 on the development of androgen-independent prostate cancer cells.

Review 2. Second-line chemotherapy in metastatic docetaxel-resistant prostate cancer: a review.

3. A Hoxb13-driven reverse tetracycline transactivator system for conditional gene expression in the prostate.

Review 4. Old issues and new perspectives on prostate cancer hormonal therapy: the molecular substratum.

5. Noncanonical Wnt signaling mediates androgen-dependent tumor growth in a mouse model of prostate cancer.

6. Castration-resistant prostate cancer: new science and therapeutic prospects.

7. Peptidomimetic targeting of critical androgen receptor-coregulator interactions in prostate cancer.

Review 8. Wnt signaling pathway protein LEF1 in cancer, as a biomarker for prognosis and a target for treatment.

Review 9. Molecular biology of androgen-independent prostate cancer: the role of the androgen receptor pathway.

10. Chromosome Y variants from different inbred mouse strains are linked to differences in the morphologic and molecular responses of cardiac cells to postpubertal testosterone.