Literature DB >> 17913246

Genetic association analysis of the interleukin 7 gene (IL7) in multiple sclerosis.

Frida Lundmark1, Kristina Duvefelt, Jan Hillert.   

Abstract

IL7 is a nonredundant cytokine, essential for T cell survival and development in humans. We genotyped nine tagging single nucleotide polymorphisms (SNP), representing all parts of the IL7 gene, in 1,210 Swedish multiple sclerosis (MS) patients and 1,234 healthy controls. None of the SNPs showed a significantly different distribution in MS, and haplotype analysis also failed to reveal differences between patients and controls. We conclude that the IL7 gene is very unlikely to influence the genetic susceptibility to MS in this population.

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Year:  2007        PMID： 17913246     DOI： 10.1016/j.jneuroim.2007.08.015

Source DB:  PubMed          Journal:  J Neuroimmunol        ISSN： 0165-5728            Impact factor:   3.478


  6 in total

1.  Genome-wide association study in a high-risk isolate for multiple sclerosis reveals associated variants in STAT3 gene.

Authors:  Eveliina Jakkula; Virpi Leppä; Anna-Maija Sulonen; Teppo Varilo; Suvi Kallio; Anu Kemppinen; Shaun Purcell; Keijo Koivisto; Pentti Tienari; Marja-Liisa Sumelahti; Irina Elovaara; Tuula Pirttilä; Mauri Reunanen; Arpo Aromaa; Annette Bang Oturai; Helle Bach Søndergaard; Hanne F Harbo; Inger-Lise Mero; Stacey B Gabriel; Daniel B Mirel; Stephen L Hauser; Ludwig Kappos; Chris Polman; Philip L De Jager; David A Hafler; Mark J Daly; Aarno Palotie; Janna Saarela; Leena Peltonen
Journal:  Am J Hum Genet       Date:  2010-02-12       Impact factor: 11.025

2.  Association Between IL7R Promoter Polymorphisms and Multiple Sclerosis in Turkish Population.

Authors:  Hasan Simsek; Hikmet Geckin; Nilay Padir Sensoz; Edward O List; Ahmet Arman
Journal:  J Mol Neurosci       Date:  2018-11-16       Impact factor: 3.444

3.  Myelin basic protein-specific TCR/HLA-DRB5*01:01 transgenic mice support the etiologic role of DRB5*01:01 in multiple sclerosis.

Authors:  Jacqueline A Quandt; Jaebong Huh; Mirza Baig; Karen Yao; Naoko Ito; Mark Bryant; Kazuyuki Kawamura; Clemencia Pinilla; Henry F McFarland; Roland Martin; Kouichi Ito
Journal:  J Immunol       Date:  2012-08-10       Impact factor: 5.422

4.  Heritability Estimation of Multiple Sclerosis Related Plasma Protein Levels in Sardinian Families with Immunochip Genotyping Data.

Authors:  Andrea Nova; Giulia Nicole Baldrighi; Teresa Fazia; Francesca Graziano; Valeria Saddi; Marialuisa Piras; Ashley Beecham; Jacob L McCauley; Luisa Bernardinelli
Journal:  Life (Basel)       Date:  2022-07-21

5.  Increased numbers of IL-7 receptor molecules on CD4+CD25-CD107a+ T-cells in patients with autoimmune diseases affecting the central nervous system.

Authors:  Nalini Kumar Vudattu; Sharon Kuhlmann-Berenzon; Mohsen Khademi; Vicki Seyfert; Thomas Olsson; Markus J Maeurer
Journal:  PLoS One       Date:  2009-08-06       Impact factor: 3.240

6.  Variants of ST8SIA1 are associated with risk of developing multiple sclerosis.

Authors:  Seema Husain; Cagri Yildirim-Toruner; Justin P Rubio; Judith Field; Marvin Schwalb; Stuart Cook; Marcella Devoto; Emilia Vitale
Journal:  PLoS One       Date:  2008-07-09       Impact factor: 3.240
  6 in total

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