Literature DB >> 17912413

Characterisation of 3-methylorcinaldehyde synthase (MOS) in Acremonium strictum: first observation of a reductive release mechanism during polyketide biosynthesis.

Andrew M Bailey1, Russell J Cox, Kate Harley, Colin M Lazarus, Thomas J Simpson, Elizabeth Skellam.   

Abstract

Isolation and sequencing of a PKS gene isolated from xenovulene-producing cultures of Acremonium strictum indicated the presence of NT-, KS-, AT-, PT-, C-MeT- and R-domains; heterologous expression in Aspergillus oryzae resulted in the production of 3-methylorcinaldehyde, demonstrating the role of the terminal reductase domain in product release.

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Year:  2007        PMID： 17912413     DOI： 10.1039/b708614h

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  31 in total

1.  Molecular genetic analysis of the orsellinic acid/F9775 gene cluster of Aspergillus nidulans.

Authors:  James F Sanchez; Yi-Ming Chiang; Edyta Szewczyk; Ashley D Davidson; Manmeet Ahuja; C Elizabeth Oakley; Jin Woo Bok; Nancy Keller; Berl R Oakley; Clay C C Wang
Journal:  Mol Biosyst       Date:  2009-12-16

2.  Microbial genome mining answers longstanding biosynthetic questions.

Authors:  Jason M Crawford; Jon Clardy
Journal:  Proc Natl Acad Sci U S A       Date:  2012-05-01       Impact factor: 11.205

3.  Classification, prediction, and verification of the regioselectivity of fungal polyketide synthase product template domains.

Authors:  Yanran Li; Image Image Image; Wei Xu; Image Image; Yi Tang; Image Image
Journal:  J Biol Chem       Date:  2010-05-17       Impact factor: 5.157

Review 4.  Cyclization of aromatic polyketides from bacteria and fungi.

Authors:  Hui Zhou; Yanran Li; Yi Tang
Journal:  Nat Prod Rep       Date:  2010-03-31       Impact factor: 13.423

Review 5.  The architectures of iterative type I PKS and FAS.

Authors:  Dominik A Herbst; Craig A Townsend; Timm Maier
Journal:  Nat Prod Rep       Date:  2018-10-17       Impact factor: 13.423

Review 6.  Unraveling polyketide synthesis in members of the genus Aspergillus.

Authors:  Yi-Ming Chiang; Berl R Oakley; Nancy P Keller; Clay C C Wang
Journal:  Appl Microbiol Biotechnol       Date:  2010-04-02       Impact factor: 4.813

7.  Comparative characterization of fungal anthracenone and naphthacenedione biosynthetic pathways reveals an α-hydroxylation-dependent Claisen-like cyclization catalyzed by a dimanganese thioesterase.

Authors:  Yanran Li; Yit-Heng Chooi; Yuewei Sheng; Joan S Valentine; Yi Tang
Journal:  J Am Chem Soc       Date:  2011-09-14       Impact factor: 15.419

8.  Genetic, molecular, and biochemical basis of fungal tropolone biosynthesis.

Authors:  Jack Davison; Ahmed al Fahad; Menghao Cai; Zhongshu Song; Samar Y Yehia; Colin M Lazarus; Andrew M Bailey; Thomas J Simpson; Russell J Cox
Journal:  Proc Natl Acad Sci U S A       Date:  2012-04-16       Impact factor: 11.205

9.  Navigating the fungal polyketide chemical space: from genes to molecules.

Authors:  Yit-Heng Chooi; Yi Tang
Journal:  J Org Chem       Date:  2012-09-13       Impact factor: 4.354

10.  Identification and characterization of the chaetoviridin and chaetomugilin gene cluster in Chaetomium globosum reveal dual functions of an iterative highly-reducing polyketide synthase.

Authors:  Jaclyn M Winter; Michio Sato; Satoru Sugimoto; Grace Chiou; Neil K Garg; Yi Tang; Kenji Watanabe
Journal:  J Am Chem Soc       Date:  2012-10-19       Impact factor: 15.419
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