BACKGROUND/AIMS: Pancreatic cancer is a leading cause of cancer-related death; the most consistently identified risk factors are smoking and family history. Our aims were to examine familial aggregations of pancreas and other cancers, and to determine the relative risk of the family members. METHODS: We prospectively collected data on the families of patients presenting with pancreatic ductal adenocarcinoma. Smoking habits and alcohol consumption of the probands were compared with the available statistics on the Italian population. Mortality from cancer was investigated in first-degree relatives, and age-dependent risks of dying from pancreatic cancer and other tumors were compared with background population levels. RESULTS: Data for 570 families were collected, including 9,204 relatives. Probands were 3- to 5-fold more often heavy smokers than the general population, and 9.3% of them reported a positive family history of pancreatic cancer. In first-degree relatives, only mortality from pancreatic cancer was significantly increased (relative risk at age 85 years = 2.7). Lifetime risk of dying of pancreas cancer was 4.1% for the relatives of all probands, and was 7.2% for the relatives of probands who developed disease before 60 years of age. CONCLUSIONS: The data suggest that genetic susceptibility to pancreatic cancer may be attributable, in addition to BRCA2, to moderate- to low-penetrance gene(s). (c) 2007 S. Karger AG, Basel and IAP.
BACKGROUND/AIMS: Pancreatic cancer is a leading cause of cancer-related death; the most consistently identified risk factors are smoking and family history. Our aims were to examine familial aggregations of pancreas and other cancers, and to determine the relative risk of the family members. METHODS: We prospectively collected data on the families of patients presenting with pancreatic ductal adenocarcinoma. Smoking habits and alcohol consumption of the probands were compared with the available statistics on the Italian population. Mortality from cancer was investigated in first-degree relatives, and age-dependent risks of dying from pancreatic cancer and other tumors were compared with background population levels. RESULTS: Data for 570 families were collected, including 9,204 relatives. Probands were 3- to 5-fold more often heavy smokers than the general population, and 9.3% of them reported a positive family history of pancreatic cancer. In first-degree relatives, only mortality from pancreatic cancer was significantly increased (relative risk at age 85 years = 2.7). Lifetime risk of dying of pancreas cancer was 4.1% for the relatives of all probands, and was 7.2% for the relatives of probands who developed disease before 60 years of age. CONCLUSIONS: The data suggest that genetic susceptibility to pancreatic cancer may be attributable, in addition to BRCA2, to moderate- to low-penetrance gene(s). (c) 2007 S. Karger AG, Basel and IAP.
Authors: S Raissouni; G Rais; H Mrabti; F Raissouni; H Mouzount; M Aitelhaj; S El Khoyaali; A Mohtaram; H Errihani Journal: J Gastrointest Cancer Date: 2012-12
Authors: Eric J Jacobs; Stephen J Chanock; Charles S Fuchs; Andrea Lacroix; Robert R McWilliams; Emily Steplowski; Rachael Z Stolzenberg-Solomon; Alan A Arslan; H Bas Bueno-de-Mesquita; Myron Gross; Kathy Helzlsouer; Gloria Petersen; Wei Zheng; Ilir Agalliu; Naomi E Allen; Laufey Amundadottir; Marie-Christine Boutron-Ruault; Julie E Buring; Federico Canzian; Sandra Clipp; Miren Dorronsoro; J Michael Gaziano; Edward L Giovannucci; Susan E Hankinson; Patricia Hartge; Robert N Hoover; David J Hunter; Kevin B Jacobs; Mazda Jenab; Peter Kraft; Charles Kooperberg; Shannon M Lynch; Malin Sund; Julie B Mendelsohn; Tracy Mouw; Christina C Newton; Kim Overvad; Domenico Palli; Petra H M Peeters; Aleksandar Rajkovic; Xiao-Ou Shu; Gilles Thomas; Geoffrey S Tobias; Dimitrios Trichopoulos; Jarmo Virtamo; Jean Wactawski-Wende; Brian M Wolpin; Kai Yu; Anne Zeleniuch-Jacquotte Journal: Int J Cancer Date: 2010-09-01 Impact factor: 7.396