Literature DB >> 17911411

ETV5 is required for continuous spermatogenesis in adult mice and may mediate blood testes barrier function and testicular immune privilege.

Carla M K Morrow1, Chris E Hostetler, Mike D Griswold, Marie-Claude Hofmann, Kenneth M Murphy, Paul S Cooke, Rex A Hess.   

Abstract

The transcription factor Ets-variant gene 5 (ETV5) is essential for spermatogonial stem cell (SSC) self-renewal, as the targeted deletion of the Etv5 gene in mice (Etv5(-/-)) results in only the first wave of spermatogenesis. Reciprocal transplants of neonatal germ cells from wild-type (WT) and Etv5(-/-) testes were performed to determine the role of ETV5 in Sertoli cells and germ cells. ETV5 appears to be needed in both cell types for normal spermatogenesis. In addition, Etv5(-/-) recipients displayed increased interstitial inflammation and tubular involution after transplantation. Preliminary studies suggest that the blood-testis barrier (Sertoli-Sertoli tight junctional complex) is abnormal in the Etv5(-/-) mouse.

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Year:  2007        PMID： 17911411      PMCID： PMC2733827          DOI： 10.1196/annals.1411.005

Source DB:  PubMed          Journal:  Ann N Y Acad Sci        ISSN： 0077-8923            Impact factor:   5.691


  19 in total

1.  Transmembrane form of the kit ligand growth factor is determined by alternative splicing and is missing in the Sld mutant.

Authors:  J G Flanagan; D C Chan; P Leder
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2.  Development of germ cell transplants in mice.

Authors:  G G Parreira; T Ogawa; M R Avarbock; L R França; R L Brinster; L D Russell
Journal:  Biol Reprod       Date:  1998-12       Impact factor: 4.285

Review 3.  IL-6 signal transduction and its physiological roles: the signal orchestration model.

Authors:  D Kamimura; K Ishihara; T Hirano
Journal:  Rev Physiol Biochem Pharmacol       Date:  2003-04-05       Impact factor: 5.545

4.  Development of germ cell transplants: morphometric and ultrastructural studies.

Authors:  G G Parreira; T Ogawa; M R Avarbock; L R França; C L Hausler; R L Brinster; L D Russell
Journal:  Tissue Cell       Date:  1999-06       Impact factor: 2.466

5.  Germline niche transplantation restores fertility in infertile mice.

Authors:  M Kanatsu-Shinohara; H Miki; K Inoue; N Ogonuki; S Toyokuni; A Ogura; T Shinohara
Journal:  Hum Reprod       Date:  2005-05-26       Impact factor: 6.918

6.  Restoration of spermatogenesis in infertile mice by Sertoli cell transplantation.

Authors:  Takashi Shinohara; Kyle E Orwig; Mary R Avarbock; Ralph L Brinster
Journal:  Biol Reprod       Date:  2003-03       Impact factor: 4.285

7.  ERM is required for transcriptional control of the spermatogonial stem cell niche.

Authors:  Chen Chen; Wenjun Ouyang; Vadim Grigura; Qing Zhou; Kay Carnes; Hyunjung Lim; Guang-Quan Zhao; Silvia Arber; Natasza Kurpios; Theresa L Murphy; Alec M Cheng; John A Hassell; Varadaraj Chandrashekar; Marie-Claude Hofmann; Rex A Hess; Kenneth M Murphy
Journal:  Nature       Date:  2005-08-18       Impact factor: 49.962

8.  Spermatogenesis following male germ-cell transplantation.

Authors:  R L Brinster; J W Zimmermann
Journal:  Proc Natl Acad Sci U S A       Date:  1994-11-22       Impact factor: 11.205

9.  Germline transmission of donor haplotype following spermatogonial transplantation.

Authors:  R L Brinster; M R Avarbock
Journal:  Proc Natl Acad Sci U S A       Date:  1994-11-22       Impact factor: 11.205

10.  Proliferation and differentiation of spermatogonial stem cells in the w/wv mutant mouse testis.

Authors:  Hiroshi Ohta; Akira Tohda; Yoshitake Nishimune
Journal:  Biol Reprod       Date:  2003-07-30       Impact factor: 4.285
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  22 in total

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Authors:  Ke Hu; Jing Zhang; Meng Liang
Journal:  In Vitro Cell Dev Biol Anim       Date:  2016-11-07       Impact factor: 2.416

3.  Testosterone regulates tight junction proteins and influences prostatic autoimmune responses.

Authors:  Jing Meng; Elahe A Mostaghel; Funda Vakar-Lopez; Bruce Montgomery; Larry True; Peter S Nelson
Journal:  Horm Cancer       Date:  2011-06       Impact factor: 3.869

4.  Sertoli cell-specific deletion of the androgen receptor compromises testicular immune privilege in mice.

Authors:  Jing Meng; Anne R Greenlee; Chloe J Taub; Robert E Braun
Journal:  Biol Reprod       Date:  2011-05-04       Impact factor: 4.285

5.  Claudin 5 expression in mouse seminiferous epithelium is dependent upon the transcription factor ets variant 5 and contributes to blood-testis barrier function.

Authors:  Carla M K Morrow; Gaurav Tyagi; Liz Simon; Kay Carnes; Kenneth M Murphy; Paul S Cooke; Marie-Claude C Hofmann; Rex A Hess
Journal:  Biol Reprod       Date:  2009-07-01       Impact factor: 4.285

Review 6.  Regulation of the spermatogonial stem cell niche.

Authors:  N Kostereva; M-C Hofmann
Journal:  Reprod Domest Anim       Date:  2008-07       Impact factor: 2.005

7.  Androgen-dependent sertoli cell tight junction remodeling is mediated by multiple tight junction components.

Authors:  Papia Chakraborty; F William Buaas; Manju Sharma; Benjamin E Smith; Anne R Greenlee; Stephen M Eacker; Robert E Braun
Journal:  Mol Endocrinol       Date:  2014-05-13

8.  Identification of glial cell line-derived neurotrophic factor-regulated genes important for spermatogonial stem cell self-renewal in the rat.

Authors:  Jonathan A Schmidt; Mary R Avarbock; John W Tobias; Ralph L Brinster
Journal:  Biol Reprod       Date:  2009-04-01       Impact factor: 4.285

9.  Transcriptome analysis of mammary epithelial subpopulations identifies novel determinants of lineage commitment and cell fate.

Authors:  Howard Kendrick; Joseph L Regan; Fiona-Ann Magnay; Anita Grigoriadis; Costas Mitsopoulos; Marketa Zvelebil; Matthew J Smalley
Journal:  BMC Genomics       Date:  2008-12-08       Impact factor: 3.969

Review 10.  Propagation of adult SSCs: from mouse to human.

Authors:  Laura A Martin; Marco Seandel
Journal:  Biomed Res Int       Date:  2013-01-01       Impact factor: 3.411
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