Literature DB >> 17911024

Potent oxindole based human beta3 adrenergic receptor agonists.

F Craig Stevens1, William E Bloomquist, Anthony G Borel, Marlene L Cohen, Christine A Droste, Mark L Heiman, Aidas Kriauciunas, Daniel J Sall, Frank C Tinsley, Cynthia D Jesudason.   

Abstract

The synthesis and biological evaluation of a series of oxindole beta(3) adrenergic receptor agonists is described. A modulation of rat atrial tachycardia was observed with substitution at the 3-position of the oxindole moiety.

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Year:  2007        PMID： 17911024     DOI： 10.1016/j.bmcl.2007.09.011

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  5 in total

1.  Insights into the binding modes of human β₃-adrenergic receptor agonists with ligand-based and receptor-based methods.

Authors:  Fangfang Jin; Chunhua Lu; Xianqiang Sun; Weihua Li; Guixia Liu; Yun Tang
Journal:  Mol Divers       Date:  2011-03-20       Impact factor: 2.943

2.  Combined Scaffold Evaluation and Systems-Level Transcriptome-Based Analysis for Accelerated Lead Optimization Reveals Ribosomal Targeting Spirooxindole Cyclopropanes.

Authors:  Kevin X Rodriguez; Erin N Howe; Emily P Bacher; Miranda Burnette; Jennifer L Meloche; Jayda Meisel; Patricia Schnepp; Xuejuan Tan; Mayland Chang; Jeremiah Zartman; Siyuan Zhang; Brandon L Ashfeld
Journal:  ChemMedChem       Date:  2019-07-01       Impact factor: 3.466

Review 3.  Therapeutic Potential of Spirooxindoles as Antiviral Agents.

Authors:  Na Ye; Haiying Chen; Eric A Wold; Pei-Yong Shi; Jia Zhou
Journal:  ACS Infect Dis       Date:  2016-05-05       Impact factor: 5.084

4.  A thermally-induced, tandem [3,3]-sigmatropic rearrangement/[2 + 2] cycloaddition approach to carbocyclic spirooxindoles.

Authors:  Kay M Brummond; Joshua M Osbourn
Journal:  Beilstein J Org Chem       Date:  2010-04-08       Impact factor: 2.883

Review 5.  Literature Survey and Further Studies on the 3-Alkylation of N-Unprotected 3-Monosubstituted Oxindoles. Practical Synthesis of N-Unprotected 3,3-Disubstituted Oxindoles and Subsequent Transformations on the Aromatic Ring.

Authors:  Eszter Kókai; Gyula Simig; Balázs Volk
Journal:  Molecules       Date:  2016-12-26       Impact factor: 4.411
  5 in total

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