Literature DB >> 17911023

3,5-Disubstituted quinolines as novel c-Jun N-terminal kinase inhibitors.

Rong Jiang1, Derek Duckett, Weiming Chen, Jeff Habel, Yuan Yuan Ling, Philip LoGrasso, Theodore M Kamenecka.   

Abstract

The structure-based design and synthesis of a novel series of c-Jun N-terminal kinase (JNK) inhibitors with selectivity against p38 is reported. The unique structure of 3,5-disubstituted quinolines (2) was developed from the previously reported 4-(2,7-phenanthrolin-9-yl)phenol (1). The X-ray crystal structure of 16a in JNK3 reveals an unexpected binding mode for this new scaffold with protein.

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Year:  2007        PMID： 17911023     DOI： 10.1016/j.bmcl.2007.08.054

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  10 in total

1.  Synthesis and SAR of 4-(pyrazol-3-yl)-pyridines as novel c-jun N-terminal kinase inhibitors.

Authors:  Romain Noël; Youseung Shin; Xinyi Song; Yuanjun He; Marcel Koenig; Weimin Chen; Yuan Yuan Ling; Li Lin; Claudia H Ruiz; Phil LoGrasso; Michael D Cameron; Derek R Duckett; Theodore M Kamenecka
Journal:  Bioorg Med Chem Lett       Date:  2010-12-01       Impact factor: 2.823

2.  Synthesis and SAR of novel isoxazoles as potent c-jun N-terminal kinase (JNK) inhibitors.

Authors:  Yuanjun He; Derek Duckett; Weimin Chen; Yuan Yuan Ling; Michael D Cameron; Li Lin; Claudia H Ruiz; Philip V Lograsso; Theodore M Kamenecka; Marcel Koenig
Journal:  Bioorg Med Chem Lett       Date:  2013-12-04       Impact factor: 2.823

3.  Small Molecule c-jun-N-terminal Kinase (JNK) Inhibitors Protect Dopaminergic Neurons in a Model of Parkinson's Disease.

Authors:  Jeremy W Chambers; Alok Pachori; Shannon Howard; Michelle Ganno; Donald Hansen; Ted Kamenecka; Xinyi Song; Derek Duckett; Weimin Chen; Yuan Yuan Ling; Lisa Cherry; Michael D Cameron; Li Lin; Claudia H Ruiz; Philip Lograsso
Journal:  ACS Chem Neurosci       Date:  2011-04-20       Impact factor: 4.418

4.  Synthesis and SAR of novel quinazolines as potent and brain-penetrant c-jun N-terminal kinase (JNK) inhibitors.

Authors:  Yuanjun He; Theodore M Kamenecka; Youseung Shin; Xinyi Song; Rong Jiang; Romain Noel; Derek Duckett; Weimin Chen; Yuan Yuan Ling; Michael D Cameron; Li Lin; Susan Khan; Marcel Koenig; Philip V LoGrasso
Journal:  Bioorg Med Chem Lett       Date:  2011-01-22       Impact factor: 2.823

5.  Chemoinformatic analysis of alkaloids isolated from Peganum genus.

Authors:  Omer Bayazeid; Tohfa Nasibova
Journal:  Mol Divers       Date:  2021-10-21       Impact factor: 3.364

6.  Synthesis, biological evaluation, X-ray structure, and pharmacokinetics of aminopyrimidine c-jun-N-terminal kinase (JNK) inhibitors.

Authors:  Ted Kamenecka; Rong Jiang; Xinyi Song; Derek Duckett; Weimin Chen; Yuan Yuan Ling; Jeff Habel; John D Laughlin; Jeremy Chambers; Mariana Figuera-Losada; Michael D Cameron; Li Lin; Claudia H Ruiz; Philip V LoGrasso
Journal:  J Med Chem       Date:  2010-01-14       Impact factor: 7.446

7.  Design and synthesis of highly potent and isoform selective JNK3 inhibitors: SAR studies on aminopyrazole derivatives.

Authors:  Ke Zheng; Sarah Iqbal; Pamela Hernandez; HaJeung Park; Philip V LoGrasso; Yangbo Feng
Journal:  J Med Chem       Date:  2014-11-21       Impact factor: 7.446

8.  Structural basis and biological consequences for JNK2/3 isoform selective aminopyrazoles.

Authors:  HaJeung Park; Sarah Iqbal; Pamela Hernandez; Rudy Mora; Ke Zheng; Yangbo Feng; Philip LoGrasso
Journal:  Sci Rep       Date:  2015-01-27       Impact factor: 4.379

9.  Inhibitors of the Detoxifying Enzyme of the Phytoalexin Brassinin Based on Quinoline and Isoquinoline Scaffolds.

Authors:  M Soledade C Pedras; Abbas Abdoli; Vijay K Sarma-Mamillapalle
Journal:  Molecules       Date:  2017-08-14       Impact factor: 4.411

10.  A reactivity model for oxidative addition to palladium enables quantitative predictions for catalytic cross-coupling reactions.

Authors:  Jingru Lu; Sofia Donnecke; Irina Paci; David C Leitch
Journal:  Chem Sci       Date:  2022-02-28       Impact factor: 9.825
  10 in total

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