Literature DB >> 17911020

Novel synthetic ligands for targeted PET imaging and radiotherapy of copper.

Hyun-Soon Chong1, Santosh Mhaske, Mai Lin, Sankar Bhuniya, Hyun A Song, Martin W Brechbiel, Xiankai Sun.   

Abstract

Novel ligands, NBEA, NBPA, NETA, NE3TA, and NE3TA-Bn, were synthesized and evaluated as potential chelators of copper radioisotopes for use in targeted positron emission tomography (PET) imaging or radiation therapy. The new ligands were radiolabeled with (64)Cu, and in vitro stability of the radiolabeled complexes was assessed in rat serum. Serum stability results suggest that among the ligands tested, NETA, NE3TA, and NE3TA-Bn form stable complexes with (64)Cu.

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Year:  2007        PMID： 17911020      PMCID： PMC2410210          DOI： 10.1016/j.bmcl.2007.09.052

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  6 in total

1.  MicroPET and autoradiographic imaging of breast cancer alpha v-integrin expression using 18F- and 64Cu-labeled RGD peptide.

Authors:  Xiaoyuan Chen; Ryan Park; Michel Tohme; Anthony H Shahinian; James R Bading; Peter S Conti
Journal:  Bioconjug Chem       Date:  2004 Jan-Feb       Impact factor: 4.774

2.  In vitro and in vivo evaluation of novel ligands for radioimmunotherapy.

Authors:  Hyun-Soon Chong; Diane E Milenic; Kayhan Garmestani; Erik D Brady; Hans Arora; Candice Pfiester; Martin W Brechbiel
Journal:  Nucl Med Biol       Date:  2006-05-02       Impact factor: 2.408

3.  In vitro and in vivo characterization of 64Cu-labeled Abegrin, a humanized monoclonal antibody against integrin alpha v beta 3.

Authors:  Weibo Cai; Yun Wu; Kai Chen; Qizhen Cao; David A Tice; Xiaoyuan Chen
Journal:  Cancer Res       Date:  2006-10-01       Impact factor: 12.701

Review 4.  Copper chelation chemistry and its role in copper radiopharmaceuticals.

Authors:  T J Wadas; E H Wong; G R Weisman; C J Anderson
Journal:  Curr Pharm Des       Date:  2007       Impact factor: 3.116

5.  Molecular imaging with copper-64.

Authors:  Suzanne V Smith
Journal:  J Inorg Biochem       Date:  2004-11       Impact factor: 4.155

6.  Synthesis and biological evaluation of novel macrocyclic ligands with pendent donor groups as potential yttrium chelators for radioimmunotherapy with improved complex formation kinetics.

Authors:  Hyun-soon Chong; Kayhan Garmestani; Dangshe Ma; Diane E Milenic; Terrish Overstreet; Martin W Brechbiel
Journal:  J Med Chem       Date:  2002-08-01       Impact factor: 7.446
  6 in total
  12 in total

Review 1.  Labeling peptides with PET radiometals: Vulcan's forge.

Authors:  Giovanni Lucignani
Journal:  Eur J Nucl Med Mol Imaging       Date:  2008-01       Impact factor: 9.236

2.  Efficient preparation and biological evaluation of a novel multivalency bifunctional chelator for 64Cu radiopharmaceuticals.

Authors:  Shuanglong Liu; Zibo Li; Li-Peng Yap; Chiun-Wei Huang; Ryan Park; Peter S Conti
Journal:  Chemistry       Date:  2011-08-04       Impact factor: 5.236

Review 3.  Molecular imaging and therapy targeting copper metabolism in hepatocellular carcinoma.

Authors:  Jason Wachsmann; Fangyu Peng
Journal:  World J Gastroenterol       Date:  2016-01-07       Impact factor: 5.742

4.  Comparison of bifunctional chelates for (64)Cu antibody imaging.

Authors:  Cara L Ferreira; Donald T T Yapp; Sarah Crisp; Brent W Sutherland; Sylvia S W Ng; Martin Gleave; Corinne Bensimon; Paul Jurek; Garry E Kiefer
Journal:  Eur J Nucl Med Mol Imaging       Date:  2010-06-16       Impact factor: 9.236

5.  New Bifunctional Chelator p-SCN-PhPr-NE3TA for Copper-64: Synthesis, Peptidomimetic Conjugation, Radiolabeling, and Evaluation for PET Imaging.

Authors:  Yongkang Gai; Lingyi Sun; Wenqi Hui; Qin Ouyang; Carolyn J Anderson; Guangya Xiang; Xiang Ma; Dexing Zeng
Journal:  Inorg Chem       Date:  2016-06-27       Impact factor: 5.165

6.  Copper-64 radiolabeling and biological evaluation of bifunctional chelators for radiopharmaceutical development.

Authors:  Ravindra A De Silva; Sandeep Jain; Kimberly A Lears; Hyun-Soon Chong; Chi Soo Kang; Xiang Sun; Buck E Rogers
Journal:  Nucl Med Biol       Date:  2012-06-27       Impact factor: 2.408

7.  Synthesis and biological evaluation of a novel decadentate ligand DEPA.

Authors:  Hyun-Soon Chong; Sooyoun Lim; Kwamena E Baidoo; Diane E Milenic; Xiang Ma; Fang Jia; Hyun A Song; Martin W Brechbiel; Michael R Lewis
Journal:  Bioorg Med Chem Lett       Date:  2008-09-19       Impact factor: 2.823

8.  Promising bifunctional chelators for copper 64-PET imaging: practical (64)Cu radiolabeling and high in vitro and in vivo complex stability.

Authors:  Ningjie Wu; Chi Soo Kang; Inseok Sin; Siyuan Ren; Dijie Liu; Varyanna C Ruthengael; Michael R Lewis; Hyun-Soon Chong
Journal:  J Biol Inorg Chem       Date:  2015-12-14       Impact factor: 3.358

9.  Transferrin conjugates of triazacyclononane-based bifunctional NE3TA chelates for PET imaging: Synthesis, Cu-64 radiolabeling, and in vitro and in vivo evaluation.

Authors:  Chi Soo Kang; Ningjie Wu; Yunwei Chen; Xiang Sun; Nilantha Bandara; Dijie Liu; Michael R Lewis; Buck E Rogers; Hyun-Soon Chong
Journal:  J Inorg Biochem       Date:  2015-10-30       Impact factor: 4.155

10.  The efficient synthesis and biological evaluation of novel bi-functionalized sarcophagine for (64)cu radiopharmaceuticals.

Authors:  Shuanglong Liu; Dan Li; Chiun-Wei Huang; Li-Peng Yap; Ryan Park; Hong Shan; Zibo Li; Peter S Conti
Journal:  Theranostics       Date:  2012-06-12       Impact factor: 11.556
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