Literature DB >> 17910959

Oleic acid: an efficient inhibitor of glucosyltransferase.

Se-Ra Won1, Mi-Jung Hong, Yong-Mu Kim, Chun Ying Li, Jang-Won Kim, Hae-Ik Rhee.   

Abstract

Among the extracts from 420 kinds of herbs, Prunus salicina, showing the highest glucosyltransferase inhibition activity, was purified and designated GTI-0163. Structural determination of GTI-0163 revealed it to be an oleic acid-based unsaturated fatty acid. GTI-0163 was an uncompetitive inhibitor of GTase. Among the unsaturated fatty acids, oleic acid showed a significantly higher GTase inhibitory activity than the saturated fatty acids or the ester form of oleic acid. These results strongly suggested that both the number of double bonds and the existence of free carboxyl groups of fatty acids play an important role in GTase inhibitory activity.

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Year:  2007        PMID： 17910959     DOI： 10.1016/j.febslet.2007.09.045

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  8 in total

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  8 in total

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