Literature DB >> 17910947

Identification of twinfilin-2 as a factor involved in neurite outgrowth by RNAi-based screen.

Shigeru Yamada1, Eiichiro Uchimura, Takanori Ueda, Takashi Nomura, Satoshi Fujita, Kayo Matsumoto, Daniel P Funeriu, Masato Miyake, Jun Miyake.   

Abstract

Using RNA interference (RNAi) to suppress gene expression, we attempted to identify tyrosine kinases involved in the extension of neurites from SH-SY5Y cells. A comprehensive analysis of gene "knock-down" profiles with small interfering RNAs (siRNAs) revealed candidate proteins that might control neurite extension. Phenotype-based screening of differentiating SH-SY5Y cells following retinoic acid (RA) stimulation indicated that twinfilin-2 is a protein that is involved in neurite outgrowth, as confirmed by morphological analysis of twinfilin-2-overexpressing cells.

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Year:  2007        PMID： 17910947     DOI： 10.1016/j.bbrc.2007.09.069

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  13 in total

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2.  TRIM47 activates NF-κB signaling via PKC-ε/PKD3 stabilization and contributes to endocrine therapy resistance in breast cancer.

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Journal:  Mol Psychiatry       Date:  2021-05-07       Impact factor: 15.992

4.  Twinfilin-2a is dispensable for mouse development.

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Journal:  Nat Commun       Date:  2015-10-30       Impact factor: 14.919

6.  A novel mode of capping protein-regulation by twinfilin.

Authors:  Adam B Johnston; Denise M Hilton; Patrick McConnell; Britney Johnson; Meghan T Harris; Avital Simone; Gaya K Amarasinghe; John A Cooper; Bruce L Goode
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9.  A loss-of-function screen for phosphatases that regulate neurite outgrowth identifies PTPN12 as a negative regulator of TrkB tyrosine phosphorylation.

Authors:  Malene Ambjørn; Véronique Dubreuil; Federico Miozzo; Fabienne Nigon; Bente Møller; Shohreh Issazadeh-Navikas; Jacob Berg; Michael Lees; Jan Sap
Journal:  PLoS One       Date:  2013-06-13       Impact factor: 3.240

10.  Phosphoproteomic profiling of selenate-treated Alzheimer's disease model cells.

Authors:  Ping Chen; Lixiang Wang; Yong Wang; Shuiming Li; Liming Shen; Qiong Liu; Jiazuan Ni
Journal:  PLoS One       Date:  2014-12-08       Impact factor: 3.240
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