Literature DB >> 17908996

A new central scaffold for metastasis: parsing HEF1/Cas-L/NEDD9.

Geraldine M O'Neill1, Sachiko Seo, Ilya G Serebriiskii, Stuart R Lessin, Erica A Golemis.   

Abstract

Greater understanding of metastasis is required to improve cancer treatment outcomes. Recently, changes in expression of the scaffold protein HEF1/CAS-L/NEDD9 were found to be a potent prometastatic stimulus in melanoma and other cancers. Mechanistic studies suggest diverse cellular roles of HEF1 and highlight its importance in the response to extracellular cues that drive invasion and metastasis. As a metastatic "hub" for signaling in cancer, HEF1 may provide a useful target for drug discovery efforts.

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Year:  2007        PMID： 17908996      PMCID： PMC2637184          DOI： 10.1158/0008-5472.CAN-07-1328

Source DB:  PubMed          Journal:  Cancer Res        ISSN： 0008-5472            Impact factor:   12.701


  28 in total

1.  Detection of peptides, proteins, and drugs that selectively interact with protein targets.

Authors:  Ilya G Serebriiskii; Olga Mitina; Elena N Pugacheva; Elizaveta Benevolenskaya; Elena Kotova; Garabet G Toby; Vladimir Khazak; William G Kaelin; Jonathan Chernoff; Erica A Golemis
Journal:  Genome Res       Date:  2002-11       Impact factor: 9.043

Review 2.  Epithelial-mesenchymal transitions in development and pathologies.

Authors:  Jean Paul Thiery
Journal:  Curr Opin Cell Biol       Date:  2003-12       Impact factor: 8.382

3.  The GDP exchange factor AND-34 is expressed in B cells, associates with HEF1, and activates Cdc42.

Authors:  Dongpo Cai; Kyriakos N Felekkis; Richard I Near; Geraldine M O'Neill; Jean Maguire van Seventer; Erica A Golemis; Adam Lerner
Journal:  J Immunol       Date:  2003-01-15       Impact factor: 5.422

4.  Identification of a set of genes with developmentally down-regulated expression in the mouse brain.

Authors:  S Kumar; Y Tomooka; M Noda
Journal:  Biochem Biophys Res Commun       Date:  1992-06-30       Impact factor: 3.575

5.  Nedd9 protein, a Cas-L homologue, is upregulated after transient global ischemia in rats: possible involvement of Nedd9 in the differentiation of neurons after ischemia.

Authors:  Takahiro Sasaki; Satoshi Iwata; Hirotaka James Okano; Yasuyo Urasaki; Junichi Hamada; Hirotoshi Tanaka; Nam H Dang; Hideyuki Okano; Chikao Morimoto
Journal:  Stroke       Date:  2005-10-06       Impact factor: 7.914

6.  Human enhancer of filamentation 1, a novel p130cas-like docking protein, associates with focal adhesion kinase and induces pseudohyphal growth in Saccharomyces cerevisiae.

Authors:  S F Law; J Estojak; B Wang; T Mysliwiec; G Kruh; E A Golemis
Journal:  Mol Cell Biol       Date:  1996-07       Impact factor: 4.272

7.  Structure and function of Cas-L, a 105-kD Crk-associated substrate-related protein that is involved in beta 1 integrin-mediated signaling in lymphocytes.

Authors:  M Minegishi; K Tachibana; T Sato; S Iwata; Y Nojima; C Morimoto
Journal:  J Exp Med       Date:  1996-10-01       Impact factor: 14.307

Review 8.  Molecular basis for HEF1/NEDD9/Cas-L action as a multifunctional co-ordinator of invasion, apoptosis and cell cycle.

Authors:  Mahendra Singh; Lauren Cowell; Sachiko Seo; Geraldine O'Neill; Erica Golemis
Journal:  Cell Biochem Biophys       Date:  2007       Impact factor: 2.194

9.  Regulation of HEF1 expression and phosphorylation by TGF-beta 1 and cell adhesion.

Authors:  Mingzhe Zheng; Paula J McKeown-Longo
Journal:  J Biol Chem       Date:  2002-08-19       Impact factor: 5.157

10.  Dissection of HEF1-dependent functions in motility and transcriptional regulation.

Authors:  Sarah J Fashena; Margret B Einarson; Geraldine M O'Neill; Christos Patriotis; Erica A Golemis
Journal:  J Cell Sci       Date:  2002-01-01       Impact factor: 5.285
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  65 in total

1.  An N-terminal truncated carboxypeptidase E splice isoform induces tumor growth and is a biomarker for predicting future metastasis in human cancers.

Authors:  Terence K Lee; Saravana R K Murthy; Niamh X Cawley; Savita Dhanvantari; Stephen M Hewitt; Hong Lou; Tracy Lau; Stephanie Ma; Thanh Huynh; Robert A Wesley; Irene O Ng; Karel Pacak; Ronnie T Poon; Y Peng Loh
Journal:  J Clin Invest       Date:  2011-03       Impact factor: 14.808

2.  NEDD9 depletion leads to MMP14 inactivation by TIMP2 and prevents invasion and metastasis.

Authors:  Sarah L McLaughlin; Ryan J Ice; Anuradha Rajulapati; Polina Y Kozyulina; Ryan H Livengood; Varvara K Kozyreva; Yuriy V Loskutov; Mark V Culp; Scott A Weed; Alexey V Ivanov; Elena N Pugacheva
Journal:  Mol Cancer Res       Date:  2013-11-07       Impact factor: 5.852

3.  Prometastatic NEDD9 Regulates Individual Cell Migration via Caveolin-1-Dependent Trafficking of Integrins.

Authors:  Polina Y Kozyulina; Yuriy V Loskutov; Varvara K Kozyreva; Anuradha Rajulapati; Ryan J Ice; Brandon C Jones; Elena N Pugacheva
Journal:  Mol Cancer Res       Date:  2014-10-15       Impact factor: 5.852

4.  Downregulation of NEDD9 by apigenin suppresses migration, invasion, and metastasis of colorectal cancer cells.

Authors:  Jin Dai; Peter G Van Wie; Leonard Yenwong Fai; Donghern Kim; Lei Wang; Pratheeshkumar Poyil; Jia Luo; Zhuo Zhang
Journal:  Toxicol Appl Pharmacol       Date:  2016-09-20       Impact factor: 4.219

5.  NSP-CAS Protein Complexes: Emerging Signaling Modules in Cancer.

Authors:  Yann Wallez; Peter D Mace; Elena B Pasquale; Stefan J Riedl
Journal:  Genes Cancer       Date:  2012-05

Review 6.  Bioinformatic approaches to augment study of epithelial-to-mesenchymal transition in lung cancer.

Authors:  Tim N Beck; Adaeze J Chikwem; Nehal R Solanki; Erica A Golemis
Journal:  Physiol Genomics       Date:  2014-08-05       Impact factor: 3.107

7.  The WW-HECT protein Smurf2 interacts with the Docking Protein NEDD9/HEF1 for Aurora A activation.

Authors:  Finola E Moore; Evan C Osmundson; Jennifer Koblinski; Elena Pugacheva; Erica A Golemis; Dipankar Ray; Hiroaki Kiyokawa
Journal:  Cell Div       Date:  2010-09-08       Impact factor: 5.130

8.  The CRTC1-NEDD9 signaling axis mediates lung cancer progression caused by LKB1 loss.

Authors:  Yan Feng; Ye Wang; Zuoyun Wang; Zhaoyuan Fang; Fei Li; Yijun Gao; Hongyan Liu; Tian Xiao; Fuming Li; Yang Zhou; Qiwei Zhai; Xiaolong Liu; Yihua Sun; Nabeel Bardeesy; Kwok-kin Wong; Haiquan Chen; Zhi-qi Xiong; Hongbin Ji
Journal:  Cancer Res       Date:  2012-10-16       Impact factor: 12.701

Review 9.  CAS proteins in health and disease: an update.

Authors:  Anna S Nikonova; Anna V Gaponova; Alexander E Kudinov; Erica A Golemis
Journal:  IUBMB Life       Date:  2014-06-24       Impact factor: 3.885

10.  A requirement for Nedd9 in luminal progenitor cells prior to mammary tumorigenesis in MMTV-HER2/ErbB2 mice.

Authors:  J L Little; V Serzhanova; E Izumchenko; B L Egleston; E Parise; A J Klein-Szanto; G Loudon; M Shubina; S Seo; M Kurokawa; M F Ochs; E A Golemis
Journal:  Oncogene       Date:  2013-01-14       Impact factor: 9.867
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