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Literature DB >> 17908555

Diabetic larvae and obese flies-emerging studies of metabolism in Drosophila.

Abstract

The past few years have seen a shift in the use of Drosophila, from studies of growth and development toward genetic characterization of carbohydrate, sterol, and lipid metabolism. This research, reviewed below, establishes a new foundation for using this simple genetic model system to define the basic regulatory mechanisms that underlie metabolic homeostasis and holds the promise of providing new insights into the causes and treatments of critical human disorders such as diabetes and obesity.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 2007 PMID： 17908555 PMCID： PMC2231808 DOI： 10.1016/j.cmet.2007.09.002

Source DB: PubMed Journal: Cell Metab ISSN： 1550-4131 Impact factor: 27.287

63 in total

1. Drosophila's insulin/PI3-kinase pathway coordinates cellular metabolism with nutritional conditions.

Authors: Jessica S Britton; Wendy K Lockwood; Ling Li; Stephen M Cohen; Bruce A Edgar
Journal: Dev Cell Date: 2002-02 Impact factor: 12.270

2. Nutrient control of gene expression in Drosophila: microarray analysis of starvation and sugar-dependent response.

Authors: Ingo Zinke; Christina S Schütz; Jörg D Katzenberger; Matthias Bauer; Michael J Pankratz
Journal: EMBO J Date: 2002-11-15 Impact factor: 11.598

Review 3. Mode of action of neuropeptides from the adipokinetic hormone family.

Authors: Gerd Gäde; Lutz Auerswald
Journal: Gen Comp Endocrinol Date: 2003-06-01 Impact factor: 2.822

4. The role of larval fat cells in adult Drosophila melanogaster.

Authors: Jerell R Aguila; Justin Suszko; Allen G Gibbs; Deborah K Hoshizaki
Journal: J Exp Biol Date: 2007-03 Impact factor: 3.312

5. Ablation of insulin-producing neurons in flies: growth and diabetic phenotypes.

Authors: Eric J Rulifson; Seung K Kim; Roel Nusse
Journal: Science Date: 2002-05-10 Impact factor: 47.728

6. Regulation of SREBP processing and membrane lipid production by phospholipids in Drosophila.

Authors: I Y Dobrosotskaya; A C Seegmiller; M S Brown; J L Goldstein; R B Rawson
Journal: Science Date: 2002-05-03 Impact factor: 47.728

7. Control of triglyceride storage by a WD40/TPR-domain protein.

Authors: Thomas Häder; Sandra Müller; Miguel Aguilera; Karsten G Eulenberg; Arnd Steuernagel; Thomas Ciossek; Ronald P Kühnlein; Lydia Lemaire; Rüdiger Fritsch; Cord Dohrmann; Ingrid R Vetter; Herbert Jäckle; Winifred W Doane; Günter Brönner
Journal: EMBO Rep Date: 2003-05 Impact factor: 8.807

8. Nutrient-dependent expression of insulin-like peptides from neuroendocrine cells in the CNS contributes to growth regulation in Drosophila.

Authors: Tomoatsu Ikeya; Milos Galic; Priyanka Belawat; Knud Nairz; Ernst Hafen
Journal: Curr Biol Date: 2002-08-06 Impact factor: 10.834

9. The Drosophila microRNA Mir-14 suppresses cell death and is required for normal fat metabolism.

Authors: Peizhang Xu; Stephanie Y Vernooy; Ming Guo; Bruce A Hay
Journal: Curr Biol Date: 2003-04-29 Impact factor: 10.834

Review 10. Insulin/IGF and target of rapamycin signaling: a TOR de force in growth control.

Authors: Sean Oldham; Ernst Hafen
Journal: Trends Cell Biol Date: 2003-02 Impact factor: 20.808

202 in total

1. Emerging roles for specific fatty acids in developmental processes.

Authors: Tracy L Vrablik; Jennifer L Watts
Journal: Genes Dev Date: 2012-04-01 Impact factor: 11.361

2. Myc Function in Drosophila.

Authors: Paola Bellosta; Peter Gallant
Journal: Genes Cancer Date: 2010-06-01

3. Genetic perturbation of key central metabolic genes extends lifespan in Drosophila and affects response to dietary restriction.

Authors: Matthew E Talbert; Brittany Barnett; Robert Hoff; Maria Amella; Kate Kuczynski; Erik Lavington; Spencer Koury; Evgeny Brud; Walter F Eanes
Journal: Proc Biol Sci Date: 2015-09-22 Impact factor: 5.349

Diabetic larvae and obese flies-emerging studies of metabolism in Drosophila.

1. Drosophila's insulin/PI3-kinase pathway coordinates cellular metabolism with nutritional conditions.

2. Nutrient control of gene expression in Drosophila: microarray analysis of starvation and sugar-dependent response.

Review 3. Mode of action of neuropeptides from the adipokinetic hormone family.

4. The role of larval fat cells in adult Drosophila melanogaster.

5. Ablation of insulin-producing neurons in flies: growth and diabetic phenotypes.

6. Regulation of SREBP processing and membrane lipid production by phospholipids in Drosophila.

7. Control of triglyceride storage by a WD40/TPR-domain protein.

8. Nutrient-dependent expression of insulin-like peptides from neuroendocrine cells in the CNS contributes to growth regulation in Drosophila.

9. The Drosophila microRNA Mir-14 suppresses cell death and is required for normal fat metabolism.

Review 10. Insulin/IGF and target of rapamycin signaling: a TOR de force in growth control.

1. Emerging roles for specific fatty acids in developmental processes.

2. Myc Function in Drosophila.

3. Genetic perturbation of key central metabolic genes extends lifespan in Drosophila and affects response to dietary restriction.

4. Bacteria-mediated hypoxia functions as a signal for mosquito development.

5. High-fat-diet-induced obesity and heart dysfunction are regulated by the TOR pathway in Drosophila.

Review 6. Transgenerational inheritance of metabolic disease.

7. Insulin-producing cells in the brain of adult Drosophila are regulated by the serotonin 5-HT1A receptor.

8. Juvenile hormone and insulin suppress lipolysis between periods of lactation during tsetse fly pregnancy.

Review 9. Modeling obesity and its associated disorders in Drosophila.

10. Feeding regulation in Drosophila.