Literature DB >> 17906993

Recurrent life-threatening ventricular dysrhythmias associated with acute hydrofluoric acid ingestion: observations in one case and implications for mechanism of toxicity.

Rais Vohra1, Larissa I Velez, Wilfredo Rivera, Fernando L Benitez, Kathleen A Delaney.   

Abstract

INTRODUCTION: Hydrofluoric acid (HF) is a weak inorganic acid used for etching and as rust remover. Systemic toxicity is manifested as ventricular dysrhythmias. The mechanisms for these dysrhythmias are not well elucidated. CASE REPORT: An 82-year-old woman ingested 8 ounces of 7% HF. Shortly after emergency department (ED) arrival, she became pulseless, developing recurrent ventricular dysrhythmias. She was defibrillated 17 times and received several doses of calcium, magnesium, and lidocaine. After three hours, she returned to sustained NSR. She was discharged home after four days. DISCUSSION: The electrocardiographic findings in this patient demonstrate hypocalcemia, which has been implicated as the culprit in HF-induced arrhythmias. However, despite correction of the hypocalcemia, the ventricular arrhythmias persisted. The proposed mechanisms of systemic HF toxicity and the relevant literature are discussed.
CONCLUSION: Ventricular dysrhythmias due to HF toxicity seem to be independent of either hypocalcemia or hyperkalemia. Systemic toxicity after ingestions may be delayed and precipitous.

Entities:  

Mesh:

Substances:

Year:  2008        PMID: 17906993     DOI: 10.1080/15563650701639097

Source DB:  PubMed          Journal:  Clin Toxicol (Phila)        ISSN: 1556-3650            Impact factor:   4.467


  7 in total

1.  Case files of the Toxikon Consortium in Chicago: survival after intentional ingestion of hydrofluoric acid.

Authors:  Patrick M Whiteley; Steven E Aks
Journal:  J Med Toxicol       Date:  2010-09

2.  Differential expression of myocardial heat shock proteins in rats acutely exposed to fluoride.

Authors:  Lakshmikanthan Panneerselvam; Azhwar Raghunath; Ekambaram Perumal
Journal:  Cell Stress Chaperones       Date:  2017-04-27       Impact factor: 3.667

3.  Intentional Toxic Ingestion of Sodium Fluoride: A Case Report.

Authors:  Rachel E Bridwell; Brandon M Carius; Eric B Tomich; Joseph K Maddry
Journal:  Cureus       Date:  2019-06-28

4.  Extracorporeal membrane oxygenation combined with continuous renal replacement therapy in cutaneous burn and inhalation injury caused by hydrofluoric acid and nitric acid.

Authors:  Qinhua Pu; Jinxian Qian; Weiyi Tao; Aixiang Yang; Jian Wu; Yaodong Wang
Journal:  Medicine (Baltimore)       Date:  2017-12       Impact factor: 1.817

Review 5.  Hydrofluoric Acid: Burns and Systemic Toxicity, Protective Measures, Immediate and Hospital Medical Treatment.

Authors:  Emilija Bajraktarova-Valjakova; Vesna Korunoska-Stevkovska; Silvana Georgieva; Kiro Ivanovski; Cvetanka Bajraktarova-Misevska; Aneta Mijoska; Anita Grozdanov
Journal:  Open Access Maced J Med Sci       Date:  2018-11-20

6.  Acute symptoms after a community hydrogen fluoride spill.

Authors:  Joo-Yong Na; Kuck-Hyun Woo; Seong-Yong Yoon; Seong-Yong Cho; In-Ung Song; Joo-An Kim; Jin-Seok Kim
Journal:  Ann Occup Environ Med       Date:  2013-09-19

7.  Occupational Hydrofluoric Acid Injury from Car and Truck Washing--Washington State, 2001-2013.

Authors:  Carolyn K Reeb-Whitaker; Carly M Eckert; Naomi J Anderson; David K Bonauto
Journal:  MMWR Morb Mortal Wkly Rep       Date:  2015-08-21       Impact factor: 17.586

  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.