C Lahiff1, O B Khiaron, N Nolan, G A Chadwick. 1. Department of Medicine, St. Columcilles Hospital, Loughlinstown, Co. Dublin, Ireland. conorlahiff@yahoo.com
Abstract
BACKGROUND: Pneumocystis carinii pneumonia (PCP) is a rare form of pneumonia associated with immune-suppression. It is common in patients with AIDS and with a CD4 count of less than 200 cells/mm(3). We report a case of PCP secondary to immune-suppression in a 41-year-old man with psoriatic arthritis being treated with the immune-modulatory agent etanercept. METHODS: Diagnosis of PCP was made histologically using tissue obtained via transbronchial biopsy. RESULTS: There was a good response to standard treatment with high-dose co-trimoxazole. CONCLUSION: This report highlights a recognised but previously unreported complication of etanercept.
BACKGROUND:Pneumocystis carinii pneumonia (PCP) is a rare form of pneumonia associated with immune-suppression. It is common in patients with AIDS and with a CD4 count of less than 200 cells/mm(3). We report a case of PCP secondary to immune-suppression in a 41-year-old man with psoriatic arthritis being treated with the immune-modulatory agent etanercept. METHODS: Diagnosis of PCP was made histologically using tissue obtained via transbronchial biopsy. RESULTS: There was a good response to standard treatment with high-dose co-trimoxazole. CONCLUSION: This report highlights a recognised but previously unreported complication of etanercept.
Authors: T R Navin; C B Beard; L Huang; C del Rio; S Lee; N J Pieniazek; J L Carter; T Le; A Hightower; D Rimland Journal: Lancet Date: 2001-08-18 Impact factor: 79.321
Authors: K Saito; S Nakayamada; K Nakano; M Tokunaga; S Tsujimura; K Nakatsuka; T Adachi; Y Tanaka Journal: Rheumatology (Oxford) Date: 2004-02-03 Impact factor: 7.580
Authors: J H Shelhamer; V J Gill; T C Quinn; S W Crawford; J A Kovacs; H Masur; F P Ognibene Journal: Ann Intern Med Date: 1996-03-15 Impact factor: 25.391
Authors: M E Weinblatt; J M Kremer; A D Bankhurst; K J Bulpitt; R M Fleischmann; R I Fox; C G Jackson; M Lange; D J Burge Journal: N Engl J Med Date: 1999-01-28 Impact factor: 91.245
Authors: Eva M Carmona; Theodore J Kottom; Deanne M Hebrink; Teng Moua; Raman-Deep Singh; Richard E Pagano; Andrew H Limper Journal: Am J Respir Cell Mol Biol Date: 2012-02-16 Impact factor: 6.914
Authors: Matthew R Gingo; Lorrie Lucht; Kieran R Daly; Kpandja Djawe; Frank J Palella; Alison G Abraham; Jay H Bream; Mallory D Witt; Lawrence A Kingsley; Karen A Norris; Peter D Walzer; Alison Morris Journal: J Acquir Immune Defic Syndr Date: 2011-07-01 Impact factor: 3.731