Literature DB >> 17906640

Interaction between the keratin cytoskeleton and eEF1Bgamma affects protein synthesis in epithelial cells.

Seyun Kim1, Juliane Kellner, Chang-Hun Lee, Pierre A Coulombe.   

Abstract

Eukaryotic elongation factor-1 (eEF1) is essential for peptide-chain elongation during translation. We report that its gamma subunit (eEF1Bgamma) specifically binds, and bundles, keratin intermediate filaments. Disrupting this interaction depresses translation by approximately 20% and selectively increases 80S ribosomes in epithelial cells, an outcome recapitulated by RNA interference-mediated silencing of eEF1Bgamma. These findings extend the emerging relationship between keratin proteins and the translational machinery.

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Year:  2007        PMID： 17906640     DOI： 10.1038/nsmb1301

Source DB:  PubMed          Journal:  Nat Struct Mol Biol        ISSN： 1545-9985            Impact factor:   15.369


  25 in total

1.  The eukaryotic translation elongation Factor 1Bgamma has a non-guanine nucleotide exchange factor role in protein metabolism.

Authors:  Anthony M Esposito; Terri Goss Kinzy
Journal:  J Biol Chem       Date:  2010-10-06       Impact factor: 5.157

2.  Role of cellular cytoskeleton in epithelial-mesenchymal transition process during cancer progression.

Authors:  B O Sun; Yantian Fang; Zhenyang Li; Zongyou Chen; Jianbin Xiang
Journal:  Biomed Rep       Date:  2015-07-27

3.  Extensive proteomic remodeling is induced by eukaryotic translation elongation factor 1Bγ deletion in Aspergillus fumigatus.

Authors:  Grainne O'Keeffe; Christoph Jöchl; Kevin Kavanagh; Sean Doyle
Journal:  Protein Sci       Date:  2013-09-30       Impact factor: 6.725

4.  Protein kinase Darkener of apricot and its substrate EF1γ regulate organelle transport along microtubules.

Authors:  Anna S Serpinskaya; Karine Tuphile; Leonard Rabinow; Vladimir I Gelfand
Journal:  J Cell Sci       Date:  2013-10-25       Impact factor: 5.285

5.  Drosophila translational elongation factor-1gamma is modified in response to DOA kinase activity and is essential for cellular viability.

Authors:  Yujie Fan; Michael Schlierf; Ana Cuervo Gaspar; Catherine Dreux; Arlette Kpebe; Linda Chaney; Aurelie Mathieu; Christophe Hitte; Olivier Grémy; Emeline Sarot; Mark Horn; Yunlong Zhao; Terri Goss Kinzy; Leonard Rabinow
Journal:  Genetics       Date:  2009-10-19       Impact factor: 4.562

6.  Mitotic modulation of translation elongation factor 1 leads to hindered tRNA delivery to ribosomes.

Authors:  Gilad Sivan; Ranen Aviner; Orna Elroy-Stein
Journal:  J Biol Chem       Date:  2011-06-10       Impact factor: 5.157

7.  "Panta rhei": Perpetual cycling of the keratin cytoskeleton.

Authors:  Rudolf E Leube; Marcin Moch; Anne Kölsch; Reinhard Windoffer
Journal:  Bioarchitecture       Date:  2011-01

Review 8.  Emerging role for the cytoskeleton as an organizer and regulator of translation.

Authors:  Seyun Kim; Pierre A Coulombe
Journal:  Nat Rev Mol Cell Biol       Date:  2010-01       Impact factor: 94.444

9.  Keratin 8 and 18 loss in epithelial cancer cells increases collective cell migration and cisplatin sensitivity through claudin1 up-regulation.

Authors:  Anne-Marie Fortier; Eric Asselin; Monique Cadrin
Journal:  J Biol Chem       Date:  2013-02-28       Impact factor: 5.157

10.  Keratins and protein synthesis: the plot thickens.

Authors:  Juliane C Kellner; Pierre A Coulombe
Journal:  J Cell Biol       Date:  2009-10-19       Impact factor: 10.539
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