BACKGROUND: Cushing's Syndrome (CS) is associated with excess and premature cardiovascular disease. Endothelial dysfunction is the initiating event in the development of atherosclerosis. Endothelial function is assessed by flow-mediated dilatation (FMD) of brachial artery. The aim of this study was to assess FMD in patients with CS. METHODS: We prospectively evaluated 22 patients with CS (12 women, 10 men; aged 42 +/- 11 years, serum cortisol 28.2 +/- 14 microg/dl, 24-h urinary free cortisol (UFC) 269 +/- 92 microg/day), and 23 control subjects (13 women, 10 men; aged 43 +/- 10 years, serum cortisol 14 +/- 4 microg/dl, 24 h cortisol 60 +/- 22 microg/day). Endothelial function, measured as FMD of the brachial artery using ultrasound, was calculated in two groups. Endothelial function was evaluated by assessing 1-min postischemic FMD of the brachial artery. RESULTS: FMD was lower in patients with CS than that in those without (11.7 +/- 4.8% vs. 15.8 +/- 3.2%, P = 0.0001, respectively). There was no significant difference between two groups regarding baseline diameter of brachial artery. But, hyperemia diameter was lower in patients with CS than without CS (3.6 +/- 0.22 mm vs. 3.9 +/- 0.19 mm, P = 0.04, respectively). CONCLUSION: Endothelium-dependent FMD may impair in patients with CS compared to controls. Measurement of endothelial function may identify high-risk individuals early and therapy to reduce or retard endothelial dysfunction in patients with CS may lead to decreased cardiovascular morbidity and mortality.
BACKGROUND:Cushing's Syndrome (CS) is associated with excess and premature cardiovascular disease. Endothelial dysfunction is the initiating event in the development of atherosclerosis. Endothelial function is assessed by flow-mediated dilatation (FMD) of brachial artery. The aim of this study was to assess FMD in patients with CS. METHODS: We prospectively evaluated 22 patients with CS (12 women, 10 men; aged 42 +/- 11 years, serum cortisol 28.2 +/- 14 microg/dl, 24-h urinary free cortisol (UFC) 269 +/- 92 microg/day), and 23 control subjects (13 women, 10 men; aged 43 +/- 10 years, serum cortisol 14 +/- 4 microg/dl, 24 h cortisol 60 +/- 22 microg/day). Endothelial function, measured as FMD of the brachial artery using ultrasound, was calculated in two groups. Endothelial function was evaluated by assessing 1-min postischemic FMD of the brachial artery. RESULTS:FMD was lower in patients with CS than that in those without (11.7 +/- 4.8% vs. 15.8 +/- 3.2%, P = 0.0001, respectively). There was no significant difference between two groups regarding baseline diameter of brachial artery. But, hyperemia diameter was lower in patients with CS than without CS (3.6 +/- 0.22 mm vs. 3.9 +/- 0.19 mm, P = 0.04, respectively). CONCLUSION: Endothelium-dependent FMD may impair in patients with CS compared to controls. Measurement of endothelial function may identify high-risk individuals early and therapy to reduce or retard endothelial dysfunction in patients with CS may lead to decreased cardiovascular morbidity and mortality.
Authors: G Arnaldi; A Angeli; A B Atkinson; X Bertagna; F Cavagnini; G P Chrousos; G A Fava; J W Findling; R C Gaillard; A B Grossman; B Kola; A Lacroix; T Mancini; F Mantero; J Newell-Price; L K Nieman; N Sonino; M L Vance; A Giustina; M Boscaro Journal: J Clin Endocrinol Metab Date: 2003-12 Impact factor: 5.958
Authors: T Neunteufl; R Katzenschlager; A Hassan; U Klaar; S Schwarzacher; D Glogar; P Bauer; F Weidinger Journal: Atherosclerosis Date: 1997-02-28 Impact factor: 5.162
Authors: S Zacharieva; I Atanassova; E Nachev; M Orbetzova; G Kirilov; K Kalinov; R Shigarminova Journal: Horm Metab Res Date: 2005-01 Impact factor: 2.936
Authors: D S Celermajer; K E Sorensen; V M Gooch; D J Spiegelhalter; O I Miller; I D Sullivan; J K Lloyd; J E Deanfield Journal: Lancet Date: 1992-11-07 Impact factor: 79.321
Authors: D S Celermajer; K E Sorensen; D Georgakopoulos; C Bull; O Thomas; J Robinson; J E Deanfield Journal: Circulation Date: 1993-11 Impact factor: 29.690
Authors: Evan R DeVallance; Kayla W Branyan; I Mark Olfert; Emidio E Pistilli; Randall W Bryner; Eric E Kelley; Jefferson C Frisbee; Paul D Chantler Journal: Exp Physiol Date: 2021-05-14 Impact factor: 2.858
Authors: Andrea M Isidori; Chiara Graziadio; Rosa Maria Paragliola; Alessia Cozzolino; Alberto G Ambrogio; Annamaria Colao; Salvatore M Corsello; Rosario Pivonello Journal: J Hypertens Date: 2015-01 Impact factor: 4.844
Authors: Alexandria D McDow; Anju Gurung; Rama Poola; Carmel Fratianni; Marc Garfinkel; Michael G Jakoby Journal: J Investig Med High Impact Case Rep Date: 2017-04-10
Authors: Joëlle C Schutten; Peter J Joris; Isidor Minović; Adrian Post; André P van Beek; Martin H de Borst; Ronald P Mensink; Stephan J L Bakker Journal: Clin Endocrinol (Oxf) Date: 2020-10-26 Impact factor: 3.478