| Literature DB >> 17904888 |
Michael R Edwards1, Louise Slater, Sebastian L Johnston.
Abstract
Type I interferon-alpha/beta play an essential role in immunity to viruses. While interferon-beta has been used as a model of a complex promoter, many of the signalling pathways leading to interferon-beta gene expression remain controversial. Recent milestones include the discovery of Toll-like receptors and RNA helicases that signal via a novel kinase complex composed of I kappa B kinase-iota/epsilon or TANK binding kinase-1. This review provides a timely summary of this rapidly expanding field, focusing specifically on the various viral RNA binding molecules and their associated signalling pathways.Entities:
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Year: 2007 PMID: 17904888 DOI: 10.1016/j.micinf.2007.06.008
Source DB: PubMed Journal: Microbes Infect ISSN: 1286-4579 Impact factor: 2.700