Literature DB >> 17904766

Vernonia polyanthes as a new source of antiulcer drugs.

Victor Barbastefano1, Maira Cola, Anderson Luiz-Ferreira, Elisângela Farias-Silva, Clélia A Hiruma-Lima, Daniel Rinaldo, Wagner Vilegas, Alba R M Souza-Brito.   

Abstract

Methanolic (VPME) and chloroformic (VPCL) extracts, obtained from the aerial parts of Vernonia polyanthes, were investigated for its antiulcerogenic properties. Administration of VPME (250 mg/kg) and VPCL (50 mg/kg) significantly inhibited the gastric mucosa damage (64% and 90%, respectively) caused by absolute ethanol (p.o.). Otherwise, in NSAID-induced gastric damage, their gastroprotective effects have decreased. Since the VPCL extract resulted to be more effective than the VPME we focused our efforts over VPCL action mechanism of action.

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Year:  2007        PMID： 17904766     DOI： 10.1016/j.fitote.2007.07.003

Source DB:  PubMed          Journal:  Fitoterapia        ISSN： 0367-326X            Impact factor:   2.882


  8 in total

1.  Anti-ulcerogenic activity of the methanol root bark extract of Cochlospermum planchonii (Hook f).

Authors:  Maxwell I Ezeja; Aruh O Anaga
Journal:  Afr J Tradit Complement Altern Med       Date:  2013-08-12

2.  Gastroprotective activity of essential oil of the Syzygium aromaticum and its major component eugenol in different animal models.

Authors:  José Roberto Santin; Marivane Lemos; Luiz Carlos Klein-Júnior; Isabel Daufenback Machado; Philipe Costa; Ana Paula de Oliveira; Crislaine Tilia; Juliana Paula de Souza; João Paulo Barreto de Sousa; Jairo Kenupp Bastos; Sérgio Faloni de Andrade
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2010-12-08       Impact factor: 3.000

3.  Phytochemical Composition and Protective Effect of Vernonanthura polyanthes Leaf against In Vivo Doxorubicin-Mediated Toxicity.

Authors:  Jamira Dias Rocha; Marilia Elias Gallon; Abel Vieira de Melo Bisneto; Vanessa Cristiane Santana Amaral; Luciane Madureira de Almeida; Leonardo Luiz Borges; Lee Chen-Chen; Leonardo Gobbo-Neto; Elisa Flávia Luiz Cardoso Bailão
Journal:  Molecules       Date:  2022-04-15       Impact factor: 4.927

4.  Antinociceptive and anti-inflammatory effects of ethanol extract from Vernonia polyanthes leaves in Rodents.

Authors:  Vanessa Dos Santos Temponi; Jucélia Barbosa Da Silva; Maria Silvana Alves; Antônia Ribeiro; José de Jesus Ribeiro Gomes de Pinho; Célia Hitomi Yamamoto; Miriam Aparecida Oliveira Pinto; Glauciemar Del-Vechio-Vieira; Orlando Vieira De Sousa
Journal:  Int J Mol Sci       Date:  2012-03-22       Impact factor: 6.208

5.  Antioxidant action of mangrove polyphenols against gastric damage induced by absolute ethanol and ischemia-reperfusion in the rat.

Authors:  Felipe Meira de-Faria; Ana Cristina Alves Almeida; Anderson Luiz-Ferreira; Christiane Takayama; Ricardo José Dunder; Marcelo Aparecido da Silva; Marcos José Salvador; Patrícia Verardi Abdelnur; Marcos Nogueira Eberlin; Wagner Vilegas; Walber Toma; Alba Regina Monteiro Souza-Brito
Journal:  ScientificWorldJournal       Date:  2012-04-30

6.  Evidence of Bioactive Compounds from Vernonia polyanthes Leaves with Topical Anti-Inflammatory Potential.

Authors:  Kamilla C M Rodrigues; Lucas A Chibli; Bruna C S Santos; Vanessa S Temponi; Nícolas C C Pinto; Elita Scio; Glauciemar Del-Vechio-Vieira; Maria S Alves; Orlando V Sousa
Journal:  Int J Mol Sci       Date:  2016-12-01       Impact factor: 5.923

7.  Study of the mechanism of anti-ulcer effects of virgin coconut oil on gastric ulcer-induced rat model.

Authors:  Jie Meng; Taoping Chen; Yu Zhao; Sucai Lu; Huiling Yu; Ying Chang; Dalei Chen
Journal:  Arch Med Sci       Date:  2018-07-05       Impact factor: 3.318

8.  Vernonia polysphaera Baker: Anti-inflammatory activity in vivo and inhibitory effect in LPS-stimulated RAW 264.7 cells.

Authors:  Iara Dos Santos da Silva Oliveira; Aracélio Viana Colares; Flávia de Oliveira Cardoso; Carla Junqueira Moragas Tellis; Maria do Socorro Dos Santos Chagas; Maria Dutra Behrens; Kátia da Silva Calabrese; Fernando Almeida-Souza; Ana Lúcia Abreu-Silva
Journal:  PLoS One       Date:  2019-12-12       Impact factor: 3.240
  8 in total

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