Literature DB >> 17904653

Emerging ideas about kisspeptin- GPR54 signaling in the neuroendocrine regulation of reproduction.

Alexander S Kauffman1, Donald K Clifton, Robert A Steiner.   

Abstract

Neurons that produce gonadotropin-releasing hormone (GnRH) drive the reproductive axis, but the molecular and cellular mechanisms by which hormonal and environmental signals regulate GnRH secretion remain poorly understood. Kisspeptins are products of the Kiss1 gene, and the interaction of kisspeptin and its receptor GPR54 plays a crucial role in governing the onset of puberty and adult reproductive function. This review discusses the latest ideas about kisspeptin-GPR54 signaling in the neuroendocrine regulation of reproduction, with special emphasis on the role of Kiss1 and kisspeptin in the negative and positive feedback control of gonadotropin secretion by sex steroids, timing of puberty onset, sexual differentiation of the brain and photoperiodic regulation of seasonal reproduction.

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Year:  2007        PMID： 17904653     DOI： 10.1016/j.tins.2007.08.001

Source DB:  PubMed          Journal:  Trends Neurosci        ISSN： 0166-2236            Impact factor:   13.837


  87 in total

Review 1.  Discovery and evolutionary history of gonadotrophin-inhibitory hormone and kisspeptin: new key neuropeptides controlling reproduction.

Authors:  K Tsutsui; G E Bentley; L J Kriegsfeld; T Osugi; J Y Seong; H Vaudry
Journal:  J Neuroendocrinol       Date:  2010-05-06       Impact factor: 3.627

2.  Female reproductive maturation in the absence of kisspeptin/GPR54 signaling.

Authors:  Christian Mayer; Ulrich Boehm
Journal:  Nat Neurosci       Date:  2011-04-24       Impact factor: 24.884

Review 3.  The neurobiology of preovulatory and estradiol-induced gonadotropin-releasing hormone surges.

Authors:  Catherine A Christian; Suzanne M Moenter
Journal:  Endocr Rev       Date:  2010-03-17       Impact factor: 19.871

Review 4.  International Union of Basic and Clinical Pharmacology. LXXVII. Kisspeptin receptor nomenclature, distribution, and function.

Authors:  Helen R Kirby; Janet J Maguire; William H Colledge; Anthony P Davenport
Journal:  Pharmacol Rev       Date:  2010-12       Impact factor: 25.468

Review 5.  The neuroendocrine basis of lactation-induced suppression of GnRH: role of kisspeptin and leptin.

Authors:  M Susan Smith; Cadence True; K L Grove
Journal:  Brain Res       Date:  2010-08-19       Impact factor: 3.252

6.  Prenatal exposure to low levels of androgen accelerates female puberty onset and reproductive senescence in mice.

Authors:  Emily A Witham; Jason D Meadows; Shadi Shojaei; Alexander S Kauffman; Pamela L Mellon
Journal:  Endocrinology       Date:  2012-07-09       Impact factor: 4.736

Review 7.  A system biology approach to identify regulatory pathways underlying the neuroendocrine control of female puberty in rats and nonhuman primates.

Authors:  Alejandro Lomniczi; Hollis Wright; Juan Manuel Castellano; Kemal Sonmez; Sergio R Ojeda
Journal:  Horm Behav       Date:  2013-07       Impact factor: 3.587

8.  Leptin action via LepR-b Tyr1077 contributes to the control of energy balance and female reproduction.

Authors:  Christa M Patterson; Eneida C Villanueva; Megan Greenwald-Yarnell; Michael Rajala; Ian E Gonzalez; Natinder Saini; Justin Jones; Martin G Myers
Journal:  Mol Metab       Date:  2012-07-26       Impact factor: 7.422

9.  Postnatal development of an estradiol-kisspeptin positive feedback mechanism implicated in puberty onset.

Authors:  Jenny Clarkson; Wah Chin Boon; Evan R Simpson; Allan E Herbison
Journal:  Endocrinology       Date:  2009-03-19       Impact factor: 4.736

Review 10.  Kisspeptin signaling in the brain.

Authors:  Amy E Oakley; Donald K Clifton; Robert A Steiner
Journal:  Endocr Rev       Date:  2009-09-21       Impact factor: 19.871
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