| Literature DB >> 17904406 |
Richard Pearson1, Jacqueline Fleetwood, Sally Eaton, Merlin Crossley, Shisan Bao.
Abstract
The Krüppel-like factor (Klfs) family of gene regulatory proteins are transcription factors implicated in many biological processes, including proliferation, apoptosis, differentiation and development. The characteristic feature of this family is the presence of three Krüppel-like zinc fingers, which bind to CACCC elements and GC-rich regions of DNA, to mediate activation and/or repression of transcription. In recent years several Klf knockout mice have been generated. The aim of this review is to outline the biological roles of those Klfs as deduced from the gene ablation studies.Entities:
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Year: 2007 PMID： 17904406 DOI： 10.1016/j.biocel.2007.07.018
Source DB: PubMed Journal: Int J Biochem Cell Biol ISSN： 1357-2725 Impact factor: 5.085