| Literature DB >> 17904123 |
Christiane A Opitz1, Neta Rimmerman, Yanmin Zhang, Laura E Mead, Mervin C Yoder, David A Ingram, J Michael Walker, Jalees Rehman.
Abstract
Recent studies have highlighted the importance of paracrine growth factors as mediators of pro-angiogenic effects by endothelial progenitor cells (EPCs), but little is known about the release of lipid-based factors like endocannabinoids by EPCs. In the current study, the release of the endocannabinoids anandamide and 2-arachidonoylglycerol by distinct human EPC sub-types was measured using HPLC/tandem mass-spectrometry. Anandamide release was highest by adult blood colony-forming EPCs at baseline and they also demonstrated increased 2-arachidonoylglycerol release with TNF-alpha stimulation. Treatment of mature endothelial cells with endocannabinoids significantly reduced the induction of the pro-inflammatory adhesion molecule CD106 (VCAM-1) by TNF-alpha.Entities:
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Year: 2007 PMID： 17904123 PMCID： PMC2072933 DOI： 10.1016/j.febslet.2007.09.032
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124