Diabetes as a determinant of high-grade carotid artery stenosis: evaluation of 1,058 cases by Doppler sonography.

Our objective was to investigate the association of risk factors, especially diabetes mellitus, with high-grade carotid artery stenosis. The study group was chosen from the patients who were sent to our Doppler ultrasonography laboratory for detecting the vascular anatomy. Doppler sonography was performed in 1,058 patients. High-grade carotid artery stenosis with a diameter reduction of 70% to 99% was detected in 89 patients. In the moderate and mild stenosis groups, we had 85 and 884 patients, respectively. Patients in the moderate stenosis group had a 40% to 69% carotid stenosis, and patients in the mild group had a 0% to 39% stenosis or normal ultrasonographic findings. Parameters of age, sex, alcohol, smoking, ischemic heart disease, hypertension, and diabetes were considered potential risk factors for stenosis. Multivariate logistic regression model was used as the statistical test in comparing the 3 groups. In the high-grade stenosis group, sex distribution was 34.8% female and 65.2% male with a mean age of 64.48 +/- 10.19 years. In the second and third groups these distributions were 51.8% female and 48.2% male with a mean age of 65.15 +/- 9.66 years, and 54.30% female and 45.70% male with a mean age 59.56 +/- 12.37, respectively. Diabetes mellitus (odds ratio [OR] = 2.77), ischemic heart disease (OR = 1.67), age (OR = 1.02), and male gender (OR = 1.75) were found to be significantly associated with high-grade carotid stenosis. As a cost-effective, noninvasive, easily performed, and fast technique, Doppler sonography is used in vascular evaluation of patients. Early diagnosis of carotid artery disease in patients with modifiable risk factors like diabetes may play an important role in the prevention of a consequent stroke.