OBJECTIVE: Using a national cancer registry, we determined the postoperative survival of patients with stage IA non-small cell lung cancer in the United States from 1988 to 1997 and identified factors that affect survival. METHODS: Within the Surveillance, Epidemiology, and End Result Program database, 10,761 patients were identified as having stage IA non-small cell lung cancer and underwent curative surgical resection from 1988 to 1997. Univariate analyses were performed by the log-rank test to determine predictors of survival, and multivariable analysis was performed by a Cox regression model. RESULTS: Overall 5-year survival was 58%. On univariate analysis, tumor size, gender, age, and extent of resection were significant predictors of survival. Five-year survival of patients with tumors 2.1 to 3.0 cm was lower than that for patients with tumors 2.0 cm or smaller: 55% versus 60% (P < .0001). Men faired significantly worse than women, with a 5-year survival of 53% versus 63% (P < .0001). Patients older than the median age of 67 years had worse 5-year survival than had those under the median age: 52% versus 65% (P < .0001). Patients undergoing sublobar resections showed poorer 5-year survival than patients undergoing anatomic resections: 44% versus 61% (P < .0001). On multivariable analysis with a Cox regression model, all 4 variables remained statistically significant. CONCLUSION: The survival of patients with stage IA non-small cell lung cancer within the United States is significantly worse than survival reported from single-institution studies. This study identifies 4 factors that may affect survival in resected stage IA non-small cell lung cancer: tumor size, gender, age, and extent of resection.
OBJECTIVE: Using a national cancer registry, we determined the postoperative survival of patients with stage IA non-small cell lung cancer in the United States from 1988 to 1997 and identified factors that affect survival. METHODS: Within the Surveillance, Epidemiology, and End Result Program database, 10,761 patients were identified as having stage IA non-small cell lung cancer and underwent curative surgical resection from 1988 to 1997. Univariate analyses were performed by the log-rank test to determine predictors of survival, and multivariable analysis was performed by a Cox regression model. RESULTS: Overall 5-year survival was 58%. On univariate analysis, tumor size, gender, age, and extent of resection were significant predictors of survival. Five-year survival of patients with tumors 2.1 to 3.0 cm was lower than that for patients with tumors 2.0 cm or smaller: 55% versus 60% (P < .0001). Men faired significantly worse than women, with a 5-year survival of 53% versus 63% (P < .0001). Patients older than the median age of 67 years had worse 5-year survival than had those under the median age: 52% versus 65% (P < .0001). Patients undergoing sublobar resections showed poorer 5-year survival than patients undergoing anatomic resections: 44% versus 61% (P < .0001). On multivariable analysis with a Cox regression model, all 4 variables remained statistically significant. CONCLUSION: The survival of patients with stage IA non-small cell lung cancer within the United States is significantly worse than survival reported from single-institution studies. This study identifies 4 factors that may affect survival in resected stage IA non-small cell lung cancer: tumor size, gender, age, and extent of resection.
Authors: Francisco Javier González-Barcala; José María García-Prim; José Manuel Alvarez-Dobaño; Milagros Moldes-Rodríguez; María Teresa García-Sanz; Antonio Pose-Reino; Luis Valdés-Cuadrado Journal: Clin Transl Oncol Date: 2010-12 Impact factor: 3.405
Authors: Laura Moreno Leon; Marine Gautier; Bernard Mari; Roger Rezzonico; Richard Allan; Marius Ilié; Nicolas Nottet; Nicolas Pons; Agnes Paquet; Kévin Lebrigand; Marin Truchi; Julien Fassy; Virginie Magnone; Garrett Kinnebrew; Milan Radovich; Meyling Hua-Chen Cheok; Pascal Barbry; Georges Vassaux; Charles-Hugo Marquette; Gilles Ponzio; Mircea Ivan; Nicolas Pottier; Paul Hofman Journal: Oncogene Date: 2019-08-15 Impact factor: 9.867
Authors: Young Joo Lee; In Kyu Park; Moo-Suk Park; Hye Jin Choi; Byoung Chul Cho; Kyung Young Chung; Se Kyu Kim; Joon Chang; Jin Wook Moon; Hoguen Kim; Sung Ho Choi; Joo-Hang Kim Journal: J Cancer Res Clin Oncol Date: 2009-06-11 Impact factor: 4.553
Authors: Anthony W Kim; Frank C Detterbeck; Daniel J Boffa; Roy H Decker; Pamela R Soulos; Laura D Cramer; Cary P Gross Journal: Ann Thorac Surg Date: 2012-07-25 Impact factor: 4.330