BACKGROUND: Frequencies of 20 MHz may be appropriate to visualize basal cell carcinomas (BCCs) including their tumor thickness and margins. Histologic comparisons to sonographic images are related at all levels of the epidermis and corium. OBJECTIVE: The objective was to evaluate whether high-frequency ultrasound (HFUS) proved to be an inexpensive and noninvasive modality to adequately delineate tumor margins under favorable circumstances. MATERIALS AND METHODS: Fifty superficial and nodular BCCs of various locations were scanned using a 20-MHz ultrasound device. Tumors were delineated, excised with 4-mm surgical margins, and sent for histologic clearance. Morpheaform, recurrent BCCs, BCCs in areas difficult to scan, and BCCs with specific properties were excluded from this study. RESULTS Clinical and ultrasonic measurements correlated well in terms of width, depth, and length (p<.0005). Of 50 BCCs, 45 were clear after margin assessment with HFUS. Five BCCs depicted extension past 4-mm surgical margins and returned with positive margins. CONCLUSION: HFUS delineated tumor margins adequately, and it appeared to depict subclinical extension past 4 mm on less aggressive BCC variants. It could be warranted if clinical or histologic diagnosis is uncertain. The strong association between clinical and ultrasonic measurements initiates more successful forms of therapy, risk-stratifies specific subgroups of patients, and prevents overall morbidity.
BACKGROUND: Frequencies of 20 MHz may be appropriate to visualize basal cell carcinomas (BCCs) including their tumor thickness and margins. Histologic comparisons to sonographic images are related at all levels of the epidermis and corium. OBJECTIVE: The objective was to evaluate whether high-frequency ultrasound (HFUS) proved to be an inexpensive and noninvasive modality to adequately delineate tumor margins under favorable circumstances. MATERIALS AND METHODS: Fifty superficial and nodular BCCs of various locations were scanned using a 20-MHz ultrasound device. Tumors were delineated, excised with 4-mm surgical margins, and sent for histologic clearance. Morpheaform, recurrent BCCs, BCCs in areas difficult to scan, and BCCs with specific properties were excluded from this study. RESULTS Clinical and ultrasonic measurements correlated well in terms of width, depth, and length (p<.0005). Of 50 BCCs, 45 were clear after margin assessment with HFUS. Five BCCs depicted extension past 4-mm surgical margins and returned with positive margins. CONCLUSION: HFUS delineated tumor margins adequately, and it appeared to depict subclinical extension past 4 mm on less aggressive BCC variants. It could be warranted if clinical or histologic diagnosis is uncertain. The strong association between clinical and ultrasonic measurements initiates more successful forms of therapy, risk-stratifies specific subgroups of patients, and prevents overall morbidity.
Authors: Rosa Ballester-Sánchez; Olga Pons-Llanas; Margarita Llavador-Ros; Rafael Botella-Estrada; Antonio Ballester-Cuñat; Alejandro Tormo-Micó; Francisco Javier Celadá-Álvarez; Silvia Rodríguez-Villalba; Manuel Santos-Ortega; Facundo Ballester-Pallarés; Jose Perez-Calatayud Journal: J Contemp Brachytherapy Date: 2014-12-31
Authors: Elisa de Oliveira Barcaui; Antonio Carlos Pires Carvalho; Flavia Paiva Proença Lobo Lopes; Juan Piñeiro-Maceira; Carlos Baptista Barcaui Journal: An Bras Dermatol Date: 2016 May-Jun Impact factor: 1.896
Authors: Francisco Bobadilla; Ximena Wortsman; Carla Muñoz; Laura Segovia; Miguel Espinoza; Gregor B E Jemec Journal: Cancer Imaging Date: 2008-09-22 Impact factor: 3.909