Literature DB >> 17901337

The slit receptor EVA-1 coactivates a SAX-3/Robo mediated guidance signal in C. elegans.

Kazuko Fujisawa1, Jeffrey L Wrana, Joseph G Culotti.   

Abstract

The SAX-3/roundabout (Robo) receptor has SLT-1/Slit-dependent and -independent functions in guiding cell and axon migrations. We identified enhancer of ventral-axon guidance defects of unc-40 mutants (EVA-1) as a Caenorhabditis elegans transmembrane receptor for SLT-1. EVA-1 has two predicted galactose-binding ectodomains, acts cell-autonomously for SLT-1/Slit-dependent axon migration functions of SAX-3/Robo, binds to SLT-1 and SAX-3, colocalizes with SAX-3 on cells, and provides cell specificity to the activation of SAX-3 signaling by SLT-1. Double mutants of eva-1 or slt-1 with sax-3 mutations suggest that SAX-3 can (when slt-1 or eva-1 function is reduced) inhibit a parallel-acting guidance mechanism, which involves UNC-40/deleted in colorectal cancer.

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Year:  2007        PMID： 17901337     DOI： 10.1126/science.1144874

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  30 in total

1.  Time-lapse imaging and cell-specific expression profiling reveal dynamic branching and molecular determinants of a multi-dendritic nociceptor in C. elegans.

Authors:  Cody J Smith; Joseph D Watson; W Clay Spencer; Tim O'Brien; Byeong Cha; Adi Albeg; Millet Treinin; David M Miller
Journal:  Dev Biol       Date:  2010-06-09       Impact factor: 3.582

Review 2.  Extracellular matrix: functions in the nervous system.

Authors:  Claudia S Barros; Santos J Franco; Ulrich Müller
Journal:  Cold Spring Harb Perspect Biol       Date:  2011-01-01       Impact factor: 10.005

Review 3.  Axon guidance events in the wiring of the mammalian olfactory system.

Authors:  Jin Hyung Cho; Janet E A Prince; Jean-François Cloutier
Journal:  Mol Neurobiol       Date:  2008-12-02       Impact factor: 5.590

4.  Skin-derived cues control arborization of sensory dendrites in Caenorhabditis elegans.

Authors:  Yehuda Salzberg; Carlos A Díaz-Balzac; Nelson J Ramirez-Suarez; Matthew Attreed; Eillen Tecle; Muriel Desbois; Zaven Kaprielian; Hannes E Bülow
Journal:  Cell       Date:  2013-10-10       Impact factor: 41.582

5.  Protein phosphatase 2A cooperates with the autophagy-related kinase UNC-51 to regulate axon guidance in Caenorhabditis elegans.

Authors:  Ken-ichi Ogura; Takako Okada; Shohei Mitani; Keiko Gengyo-Ando; David L Baillie; Yuji Kohara; Yoshio Goshima
Journal:  Development       Date:  2010-04-14       Impact factor: 6.868

6.  C. elegans ten-1 is synthetic lethal with mutations in cytoskeleton regulators, and enhances many axon guidance defective mutants.

Authors:  Catarina Mörck; Vivekanand Vivekanand; Gholamali Jafari; Marc Pilon
Journal:  BMC Dev Biol       Date:  2010-05-24       Impact factor: 1.978

Review 7.  Timing mechanisms in neuronal pathfinding, synaptic reorganization, and neuronal regeneration.

Authors:  Evguenia Ivakhnitskaia; Kana Hamada; Chieh Chang
Journal:  Dev Growth Differ       Date:  2016-01-09       Impact factor: 2.053

8.  Pioneer longitudinal axons navigate using floor plate and Slit/Robo signals.

Authors:  W Todd Farmer; Amy L Altick; Hikmet Feyza Nural; James P Dugan; Thomas Kidd; Frédéric Charron; Grant S Mastick
Journal:  Development       Date:  2008-10-08       Impact factor: 6.868

9.  CLEC-38, a transmembrane protein with C-type lectin-like domains, negatively regulates UNC-40-mediated axon outgrowth and promotes presynaptic development in Caenorhabditis elegans.

Authors:  Gauri Kulkarni; Haichang Li; William G Wadsworth
Journal:  J Neurosci       Date:  2008-04-23       Impact factor: 6.167

Review 10.  SYD-1 Promotes Multiple Developmental Steps Leading to Neuronal Connectivity.

Authors:  Yan Xu; Christopher C Quinn
Journal:  Mol Neurobiol       Date:  2015-12-11       Impact factor: 5.590
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