Literature DB >> 179008

Production of yeast alcohol dehydrogenase isoenzymes by selection.

C Wills.   

Abstract

Mutants of yeast alcohol dehydrogenase have been produced that protect the cell against the poisonous aldehyde acrolein by increasing the NADH-NAD ratio. The altered properties include changes both in binding constants and in cooperativity. Such mutants may be useful in exploring the nature of adaptation at the molecular level.

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Year:  1976        PMID： 179008     DOI： 10.1038/261026a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  19 in total

1.  A sampling of the yeast proteome.

Authors:  B Futcher; G I Latter; P Monardo; C S McLaughlin; J I Garrels
Journal:  Mol Cell Biol       Date:  1999-11       Impact factor: 4.272

2.  Zymomonas mobilis Mutants with an Increased Rate of Alcohol Production.

Authors:  Y A Osman; L O Ingram
Journal:  Appl Environ Microbiol       Date:  1987-07       Impact factor: 4.792

3.  A novel ancestral protein of Drosophila alcohol dehydrogenase in Streptomyces?

Authors:  A Freriksen; P W Heinstra
Journal:  Biochem Genet       Date:  1993-10       Impact factor: 1.890

4.  Evolution of the alcohol dehydrogenase (ADH) genes in yeast: characterization of a fourth ADH in Kluyveromyces lactis.

Authors:  D H Shain; C Salvadore; C L Denis
Journal:  Mol Gen Genet       Date:  1992-04

5.  Reduction of acetaldehyde to ethanol by some micro-organisms and its stereospecificity.

Authors:  E Maconi; A Griffini; V Cavazzoni; F Aragozzini
Journal:  Biochem J       Date:  1988-03-15       Impact factor: 3.857

6.  Mutation-absorption model of the enzyme.

Authors:  M Conrad
Journal:  Bull Math Biol       Date:  1979       Impact factor: 1.758

7.  Improved bioethanol production using CRISPR/Cas9 to disrupt the ADH2 gene in Saccharomyces cerevisiae.

Authors:  Ting Xue; Kui Liu; Duo Chen; Xue Yuan; Jingping Fang; Hansong Yan; Luqiang Huang; Youqiang Chen; Wenjin He
Journal:  World J Microbiol Biotechnol       Date:  2018-10-01       Impact factor: 3.312

8.  Human liver alcohol dehydrogenase: amino acid substitution in the beta 2 beta 2 Oriental isozyme explains functional properties, establishes an active site structure, and parallels mutational exchanges in the yeast enzyme.

Authors:  H Jörnvall; J Hempel; B L Vallee; W F Bosron; T K Li
Journal:  Proc Natl Acad Sci U S A       Date:  1984-05       Impact factor: 11.205

9.  Bradykinetic alcohol dehydrogenases make yeast fitter for growth in the presence of allyl alcohol.

Authors:  Bryce V Plapp; Ann Ting-I Lee; Aditi Khanna; John M Pryor
Journal:  Chem Biol Interact       Date:  2012-11-27       Impact factor: 5.192

10.  Functional alcohol dehydrogenase mutants of Saccharomyces cerevisiae conferring temperature-conditional allyl alcohol resistance.

Authors:  J G Hall; C Wills
Journal:  Genetics       Date:  1987-01       Impact factor: 4.562
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