Literature DB >> 17900699

Mould breakthrough in immunosuppressed adults receiving anidulafungin: a report of 2 cases.

Gene A Wetzstein1, Myke R Green, John N Greene.   

Abstract

Anidulafungin is a semi-synthetic echinocandin antifungal agent indicated for treatment of candidemia and invasive candidiasis. In vitro and clinical data indicate activity of anidulafungin toward invasive mould infections, however, clinical data in human subjects is limited. A paucity of data exists regarding breakthrough mould infections in immunocompromised patients receiving anidulafungin. We report on two immunocompromised adult patients undergoing therapy for hematologic malignancies who developed probable breakthrough mould infections while receiving anidulafungin.

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Year:  2007        PMID: 17900699     DOI: 10.1016/j.jinf.2007.08.003

Source DB:  PubMed          Journal:  J Infect        ISSN: 0163-4453            Impact factor:   6.072


  4 in total

1.  Comparative Pharmacodynamics of Echinocandins against Aspergillus fumigatus Using an In Vitro Pharmacokinetic/Pharmacodynamic Model That Correlates with Clinical Response to Caspofungin Therapy: Is There a Place for Dose Optimization?

Authors:  Maria Siopi; David S Perlin; Maiken C Arendrup; Spyros Pournaras; Joseph Meletiadis
Journal:  Antimicrob Agents Chemother       Date:  2021-03-18       Impact factor: 5.191

2.  A multicentre study to optimize echinocandin susceptibility testing of Aspergillus species with the EUCAST methodology and a broth microdilution colorimetric method.

Authors:  Joseph Meletiadis; Maria Siopi; Lamprini Kanioura; Karin Meinike Jørgensen; David S Perlin; Johan W Mouton; Maiken Cavling Arendrup
Journal:  J Antimicrob Chemother       Date:  2020-07-01       Impact factor: 5.790

3.  Caspofungin Treatment of Aspergillus fumigatus Results in ChsG-Dependent Upregulation of Chitin Synthesis and the Formation of Chitin-Rich Microcolonies.

Authors:  Louise A Walker; Keunsook K Lee; Carol A Munro; Neil A R Gow
Journal:  Antimicrob Agents Chemother       Date:  2015-07-13       Impact factor: 5.191

4.  Fungal echinocandin resistance.

Authors:  Louise A Walker; Neil A R Gow; Carol A Munro
Journal:  Fungal Genet Biol       Date:  2009-09-19       Impact factor: 3.495

  4 in total

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