H Meden-Vrtovec1, B Vrtovec, J Osredkar. 1. Department of Obstetrics and Gynecology, University Medical Centre Ljubljana, Ljubljana, Slovenia. helena.meden@kclj.si
Abstract
OBJECTIVE: To analyze the relationship between QTc interval and cardiovascular risk factors in women with polycystic ovary syndrome (PCOS). METHODS: Study group included 119 PCOS women (age: 32.2+/-5.2 years) and the control group 64 age-matched healthy women; they all underwent QT interval measurement, and plasma levels of high-sensitivity CRP (hsCRP), endothelin-1 (ET1), insulin, and testosterone determinations. RESULTS: In PCOS women hsCRP (2.35+/-2.14 mg/L vs. 1.01+/-1.28 mg/L; P=0.04), ET1 (23.6+/-10.3 ng/L vs. 7.7+/-15.9 ng/L; P=0.01), and insulin (16.5+/-7.8 mIU/L vs. 11.8+/-10.7 mIU/L; P=0.03) levels were significantly higher, and QTc interval significantly shorter than in controls (401+/-61 ms vs. 467+/-61 ms; P=0.007). In 67 (56%) PCOS patients with a short QTc interval (<400 ms), plasma testosterone levels were significantly higher than in PCOS women with normal QTc interval (2.3+/-2.1 nmol/L vs. 1.4+/-1.7 nmol/L; P=0.02). CONCLUSIONS: In patients with polycystic ovary syndrome increased testosterone levels may attenuate the effects of coronary risk factors.
OBJECTIVE: To analyze the relationship between QTc interval and cardiovascular risk factors in women with polycystic ovary syndrome (PCOS). METHODS: Study group included 119 PCOSwomen (age: 32.2+/-5.2 years) and the control group 64 age-matched healthy women; they all underwent QT interval measurement, and plasma levels of high-sensitivity CRP (hsCRP), endothelin-1 (ET1), insulin, and testosterone determinations. RESULTS: In PCOSwomen hsCRP (2.35+/-2.14 mg/L vs. 1.01+/-1.28 mg/L; P=0.04), ET1 (23.6+/-10.3 ng/L vs. 7.7+/-15.9 ng/L; P=0.01), and insulin (16.5+/-7.8 mIU/L vs. 11.8+/-10.7 mIU/L; P=0.03) levels were significantly higher, and QTc interval significantly shorter than in controls (401+/-61 ms vs. 467+/-61 ms; P=0.007). In 67 (56%) PCOSpatients with a short QTc interval (<400 ms), plasma testosterone levels were significantly higher than in PCOSwomen with normal QTc interval (2.3+/-2.1 nmol/L vs. 1.4+/-1.7 nmol/L; P=0.02). CONCLUSIONS: In patients with polycystic ovary syndrome increased testosterone levels may attenuate the effects of coronary risk factors.
Authors: A Makedos; D G Goulis; M Arvanitidou; G Mintziori; A Papanikolaou; A Makedou; D Panidis Journal: Hippokratia Date: 2011-10 Impact factor: 0.471