BACKGROUND: We investigated aspirin-prescribing patterns and potential benefits on cardiovascular morbidity and mortality in hemodialysis patients. STUDY DESIGN: Cohort study. SETTING & PARTICIPANTS: Data included 28,320 randomly selected hemodialysis patients from the Dialysis Outcomes and Practice Patterns Study I and II. PREDICTOR: Aspirin prescription at study baseline. OUTCOMES & MEASUREMENTS: Prescription was investigated by means of logistic regression. All-cause mortality, all-cause hospitalization, cardiac event, myocardial infarction, cerebrovascular (CVA), gastrointestinal bleed, transient ischemic attack, and subdural hematoma were examined. Cox regression examined the risk of mortality and hospitalization. All models accounted for facility clustering and demographics and comorbid conditions. RESULTS: Wide variation was found in aspirin prescription, from 8% in Japan to 41% in Australia and New Zealand. Characteristics significantly associated with increased odds of prescription included coronary artery disease, cerebrovascular disease, diabetes, male sex, nonblack race, peripheral vascular disease, age, hypertension, and absence of gastrointestinal bleeding. Aspirin was associated with decreased risk of stroke in all patients (relative risk [RR], 0.82; P < 0.01) and increased risk of myocardial infarction (RR, 1.21; P = 0.01) and cardiac event (RR, 1.08; P < 0.01) in all patients, with similar results for patients with coronary artery disease. There was no increase in gastrointestinal bleeding. LIMITATIONS: Observational studies are not protected from biases, despite adjustments. There is potential for aspirin use to be underreported because of its availability without prescription. CONCLUSIONS: The hypothesis that prescribing aspirin to hemodialysis patients decreases cardiovascular disease risk is not supported. Aspirin might decrease CVA and appears not to increase hemorrhagic risk. This should be an incentive for randomized controlled trials.
RCT Entities:
BACKGROUND: We investigated aspirin-prescribing patterns and potential benefits on cardiovascular morbidity and mortality in hemodialysis patients. STUDY DESIGN: Cohort study. SETTING & PARTICIPANTS: Data included 28,320 randomly selected hemodialysis patients from the Dialysis Outcomes and Practice Patterns Study I and II. PREDICTOR: Aspirin prescription at study baseline. OUTCOMES & MEASUREMENTS: Prescription was investigated by means of logistic regression. All-cause mortality, all-cause hospitalization, cardiac event, myocardial infarction, cerebrovascular (CVA), gastrointestinal bleed, transient ischemic attack, and subdural hematoma were examined. Cox regression examined the risk of mortality and hospitalization. All models accounted for facility clustering and demographics and comorbid conditions. RESULTS: Wide variation was found in aspirin prescription, from 8% in Japan to 41% in Australia and New Zealand. Characteristics significantly associated with increased odds of prescription included coronary artery disease, cerebrovascular disease, diabetes, male sex, nonblack race, peripheral vascular disease, age, hypertension, and absence of gastrointestinal bleeding. Aspirin was associated with decreased risk of stroke in all patients (relative risk [RR], 0.82; P < 0.01) and increased risk of myocardial infarction (RR, 1.21; P = 0.01) and cardiac event (RR, 1.08; P < 0.01) in all patients, with similar results for patients with coronary artery disease. There was no increase in gastrointestinal bleeding. LIMITATIONS: Observational studies are not protected from biases, despite adjustments. There is potential for aspirin use to be underreported because of its availability without prescription. CONCLUSIONS: The hypothesis that prescribing aspirin to hemodialysis patientsdecreases cardiovascular disease risk is not supported. Aspirin might decrease CVA and appears not to increase hemorrhagic risk. This should be an incentive for randomized controlled trials.
Authors: Manish M Sood; Maria Larkina; Jyothi R Thumma; Francesca Tentori; Brenda W Gillespie; Shunichi Fukuhara; David C Mendelssohn; Kevin Chan; Patricia de Sequera; Paul Komenda; Claudio Rigatto; Bruce M Robinson Journal: Kidney Int Date: 2013-05-15 Impact factor: 10.612
Authors: Stephen M Sozio; Paige A Armstrong; Josef Coresh; Bernard G Jaar; Nancy E Fink; Laura C Plantinga; Neil R Powe; Rulan S Parekh Journal: Am J Kidney Dis Date: 2009-04-19 Impact factor: 8.860
Authors: Takeshi Hasegawa; Stacey J Elder; Jennifer L Bragg-Gresham; Ronald L Pisoni; Shin Yamazaki; Tadao Akizawa; Michel Jadoul; Rayner C Hugh; Friedrich K Port; Shunichi Fukuhara Journal: Clin J Am Soc Nephrol Date: 2008-07-02 Impact factor: 8.237