Literature DB >> 17900167

Combinatorial Knoevenagel reactions.

Sergey V Ryabukhin1, Andrey S Plaskon, Dmitriy M Volochnyuk, Sergey E Pipko, Alexander N Shivanyuk, Andrey A Tolmachev.   

Abstract

Chlorotrimethylsilane (TMSCl) has been utilized as an efficient promoter and water scavenger in the Knoevenagel condensations of aromatic aldehydes with various methylene active compounds. High yields and a simple workup of target compounds enables the facile generation of combinatorial libraries comprising 11,000 compounds of high structural and functional diversity.

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Year:  2007        PMID: 17900167     DOI: 10.1021/cc070073f

Source DB:  PubMed          Journal:  J Comb Chem        ISSN: 1520-4766


  6 in total

1.  Aminoheterocycles as synthons for combinatorial Biginelli reactions.

Authors:  Sergey V Ryabukhin; Andrey S Plaskon; Sergey Yu Boron; Dmitriy M Volochnyuk; Andrey A Tolmachev
Journal:  Mol Divers       Date:  2010-05-07       Impact factor: 2.943

2.  Use of silver carbonate in the Wittig reaction.

Authors:  Lukas Jedinak; LaToya Rush; Mijoon Lee; Dusan Hesek; Jed F Fisher; Bill Boggess; Bruce C Noll; Shahriar Mobashery
Journal:  J Org Chem       Date:  2013-11-26       Impact factor: 4.354

3.  Combinatorial synthesis of chemical building blocks 1. Azomethines.

Authors:  Sergey V Ryabukhin; Dmitriy M Panov; Andrey S Plaskon; Alexander Chuprina; Sergey E Pipko; Andrey A Tolmachev; Alexander N Shivanyuk
Journal:  Mol Divers       Date:  2012-10-30       Impact factor: 2.943

4.  Enantio- and diastereoselective intermolecular Stetter reaction of glyoxamide and alkylidene ketoamides.

Authors:  Qin Liu; Tomislav Rovis
Journal:  Org Lett       Date:  2009-07-02       Impact factor: 6.005

5.  Synthesis and characterization of (Z)-5-arylmethylidene-rhodanines with photosynthesis-inhibiting properties.

Authors:  Veronika Opletalova; Jan Dolezel; Katarina Kralova; Matus Pesko; Jiri Kunes; Josef Jampilek
Journal:  Molecules       Date:  2011-06-22       Impact factor: 4.411

6.  Metal-free domino amination-Knoevenagel condensation approach to access new coumarins as potent nanomolar inhibitors of VEGFR-2 and EGFR.

Authors:  Essam M Eliwa; Marcel Frese; Ahmed H Halawa; Maha M Soltan; Larissa V Ponomareva; Jon S Thorson; Khaled A Shaaban; Mohamed Shaaban; Ahmed M El-Agrody; Norbert Sewald
Journal:  Green Chem Lett Rev       Date:  2021-09-24       Impact factor: 6.016

  6 in total

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