| Literature DB >> 17897764 |
B C Cavalcanti1, D J Moura, R M Rosa, M O Moraes, E C C Araujo, M A S Lima, E R Silveira, J Saffi, J A P Henriques, C Pessoa, L V Costa-Lotufo.
Abstract
The genotoxic effect of two tanshinones isolated from roots of Hyptis martiussi Benth (Labiatae) was studied using V79 (Chinese hamster lung) cells by the alkaline comet assay and micronucleus test. Tanshinones were incubated with the cells at concentrations of 1, 3, 6 and 12 microg/mL for 3 h. Tanshinones were shown to be quite strongly genotoxic against V79 cells at all tested concentrations. The data obtained provide support to the view that tanshinones has DNA damaging activity in cultured V79 cells under the conditions of the assays.Entities:
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Year: 2007 PMID： 17897764 DOI： 10.1016/j.fct.2007.08.009
Source DB: PubMed Journal: Food Chem Toxicol ISSN： 0278-6915 Impact factor: 6.023