Connective tissues of the periodontium. Research and clinical implications.

The periodontium is a complex anatomical site composed of a variety of hard and soft connective tissues. The site is subjected to enormous daily chemical and mechanical abuse, yet, for the most part remains relatively intact. Nonetheless, when breakdown does occur, the ability of the periodontium to regenerate is sometimes limited. This review considers the various components of the periodontium and how they might be involved in not only the pathology of periodontal diseases but also the various reparative and regenerative processes required during wound healing. In addition, the importance of external factors such as a variety of commonly prescribed medications on these events is discussed.