Literature DB >> 17897097

Insulin releasing properties of the temporin family of antimicrobial peptides.

Yasser H A Abdel-Wahab1, Lamin Marenah, Peter R Flatt, J Michael Conlon.   

Abstract

Temporin-1Vb, -1Oe, -1DRb, and -1TGb (10(-8) -10(-6)M) produced significant (p<0.05) and concentration-dependent stimulatory effects on insulin secretion from clonal rat BRIN-BD11 cells without increased release of lactate dehydrogenase. Temporin-1Va and temporin-1Vc (10(-8) - 10(-6)M) also stimulated insulin-release but were cytotoxic at 10(-6)M. Temporin-1DRa was without effect. The temporins at 10(-7) M had no effect on intracellular calcium concentrations suggesting that they stimulate insulin release via a K(ATP) channel- independent pathway.

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Year:  2007        PMID： 17897097     DOI： 10.2174/092986607781483822

Source DB:  PubMed          Journal:  Protein Pept Lett        ISSN： 0929-8665            Impact factor:   1.890


  6 in total

1.  Activity optimization of an undecapeptide analogue derived from a frog-skin antimicrobial peptide.

Authors:  Hyung-Sik Won; Su-Jin Kang; Wahn-Soo Choi; Bong-Jin Lee
Journal:  Mol Cells       Date:  2010-11-23       Impact factor: 5.034

2.  A Novel Insulinotropic Peptide from the Skin Secretions of Amolops loloensis Frog.

Authors:  Guo-Xiang Mo; Xue-Wei Bai; Zong-Jie Li; Xiu-Wen Yan; Xiao-Qing He; Ming-Qiang Rong
Journal:  Nat Prod Bioprospect       Date:  2014-10-08

3.  Role of Disulfide Bonds in Activity and Stability of Tigerinin-1R.

Authors:  Xiaolong Chen; Cuihua Hu; Yibing Huang; Yuxin Chen
Journal:  Int J Mol Sci       Date:  2018-01-23       Impact factor: 5.923

4.  Insulin Secretory Actions of Ethanol Extract of Eucalyptus citriodora Leaf, including Plasma DPP-IV and GLP-1 Levels in High-Fat-Fed Rats, as Well as Characterization of Biologically Effective Phytoconstituents.

Authors:  Prawej Ansari; Samara T Choudhury; Yasser H A Abdel-Wahab
Journal:  Metabolites       Date:  2022-08-17

5.  Effects of Spirulina platensis on insulin secretion, dipeptidyl peptidase IV activity and both carbohydrate digestion and absorption indicate potential as an adjunctive therapy for diabetes.

Authors:  J M A Hannan; Prawej Ansari; Shofiul Azam; Peter R Flatt; Yasser H A Abdel Wahab
Journal:  Br J Nutr       Date:  2020-06-10       Impact factor: 3.718

Review 6.  Antimicrobial Peptides from Amphibian Innate Immune System as Potent Antidiabetic Agents: A Literature Review and Bioinformatics Analysis.

Authors:  Hossein Soltaninejad; Hadi Zare-Zardini; Mahtab Ordooei; Yaser Ghelmani; Akram Ghadiri-Anari; Sanaz Mojahedi; Amir Ali Hamidieh
Journal:  J Diabetes Res       Date:  2021-06-29       Impact factor: 4.011
  6 in total

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