Literature DB >> 17897083

5-HT7 receptor ligands: recent developments and potential therapeutic applications.

Valeria Pittalà1, Loredana Salerno, Maria Modica, Maria Angela Siracusa, Giuseppe Romeo.   

Abstract

The 5-HT(7) receptors (5-HT(7)Rs) are the most recent classified members of the serotonin family. Characterized in 1993, they belong to the G protein-coupled receptor family. Since their discovery, they have been the subject of intense research due to their widespread distribution in the brain, suggestive of multiple central roles. The focus of this review is to discuss the literature concerning recent advances on 5-HT(7)Rs and their ligands.

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Year:  2007        PMID： 17897083     DOI： 10.2174/138955707781662663

Source DB:  PubMed          Journal:  Mini Rev Med Chem        ISSN： 1389-5575            Impact factor:   3.862


  8 in total

Review 1.  Serotonin 5-HT7 receptor agents: Structure-activity relationships and potential therapeutic applications in central nervous system disorders.

Authors:  Marcello Leopoldo; Enza Lacivita; Francesco Berardi; Roberto Perrone; Peter B Hedlund
Journal:  Pharmacol Ther       Date:  2010-10-20       Impact factor: 12.310

2.  Effect of 5-HT7 receptor agonist, LP-211, on micturition following spinal cord injury in male rats.

Authors:  Abbas Norouzi-Javidan; Javad Javanbakht; Fardin Barati; Nahid Fakhraei; Fatemeh Mohammadi; Ahmad Reza Dehpour
Journal:  Am J Transl Res       Date:  2016-06-15       Impact factor: 4.060

Review 3.  Glioblastoma chemotherapy adjunct via potent serotonin receptor-7 inhibition using currently marketed high-affinity antipsychotic medicines.

Authors:  R E Kast
Journal:  Br J Pharmacol       Date:  2010-10       Impact factor: 8.739

4.  LP-211 is a brain penetrant selective agonist for the serotonin 5-HT(7) receptor.

Authors:  Peter B Hedlund; Marcello Leopoldo; Silvio Caccia; Gor Sarkisyan; Claudia Fracasso; Giuliana Martelli; Enza Lacivita; Francesco Berardi; Roberto Perrone
Journal:  Neurosci Lett       Date:  2010-06-23       Impact factor: 3.046

5.  Towards metabolically stable 5-HT7 receptor ligands: a study on 1-arylpiperazine derivatives and related isosters.

Authors:  Enza Lacivita; Paola De Giorgio; Daniela Patarnello; Mauro Niso; Nicola A Colabufo; Francesco Berardi; Roberto Perrone; Grzegorz Satala; Beata Duszynska; Andrzej J Bojarski; Marcello Leopoldo
Journal:  Exp Brain Res       Date:  2013-04-10       Impact factor: 1.972

6.  The arylpiperazine derivatives N-(4-cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide and N-benzyl-4-(2-diphenyl)-1-piperazinehexanamide exert a long-lasting inhibition of human serotonin 5-HT7 receptor binding and cAMP signaling.

Authors:  Patricio Atanes; Enza Lacivita; Javier Rodríguez; José Brea; Javier Burgueño; José Miguel Vela; María Isabel Cadavid; María Isabel Loza; Marcello Leopoldo; Marián Castro
Journal:  Pharmacol Res Perspect       Date:  2013-12-05

7.  Effect of the probiotic Lactobacillus plantarum IS-10506 on BDNF and 5HT stimulation: role of intestinal microbiota on the gut-brain axis.

Authors:  Reza Ranuh; Alpha Fardah Athiyyah; Andy Darma; Vitria Prasetyo Risky; Wibi Riawan; Ingrid S Surono; Subijanto Marto Sudarmo
Journal:  Iran J Microbiol       Date:  2019-04

8.  Serotonin 5-HT7 receptor agonist, LP-211, exacerbates Na(+), K(+)-ATPase/Mg(2+)-ATPase imbalances in spinal cord-injured male rats.

Authors:  Abbas Norouzi-Javidan; Javad Javanbakht; Fardin Barati; Nahid Fakhraei; Fatemeh Mohammadi; Ahmad Reza Dehpour
Journal:  Diagn Pathol       Date:  2015-09-14       Impact factor: 2.644
  8 in total

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