Galit Pelled1, Hagai Bergman, Tamir Ben-Hur, Gadi Goelman. 1. MRI/MRS Laboratory, Human Biology Research Center, Department of Medical Biophysics and Nuclear Medicine, Hadassah Hebrew University Medical Center, Jerusalem, Israel.
Abstract
PURPOSE: To measure intra- and inter-hemispheric connectivity within the basal ganglia (BG) nuclei in healthy and in unilateral 6-hydroxydopamine (6-OHDA) Parkinson disease rat model in order to test the BG interhemispheric connectivity hypothesis. MATERIAL AND METHODS: The manganese-enhanced MRI (MEMRI) method with direct injection of manganese chloride into the entopeduncular (EP), substantia nigra (SN), and the Habenula nuclei in unilateral 6-OHDA (N = 22) and sham-operated (N = 16) rat groups was used. MEMRI measurements were applied before, 3, 24, and 48 hours post-manganese injection. Signal enhancements in T1-weighted images were compared between groups. RESULTS: Manganese injection into the EP nucleus resulted with bihemispheric signal enhancements in the habenular complex (Hab) at both groups with stronger enhancements in the 6-OHDA group. It also exhibited lower sensorimotor cortex signal enhancement in the 6-OHDA rat group. SN manganese injection caused enhanced anteroventral thalamic and habenular nuclei signals in the 6-OHDA rat group. Manganese habenula injection revealed enhanced interpeduncular (IP) and raphe nuclei signals of the 6-OHDA rat group. CONCLUSION: Modulations in the effective intra- and interhemispheric BG connectivity in unilateral 6-OHDA Parkinson's disease (PD) rat model support the BG interhemispheric connectivity hypothesis and suggest a linkage between the dopaminergic and serotonergic systems in PD, in line with clinical symptoms. (c) 2007 Wiley-Liss, Inc.
PURPOSE: To measure intra- and inter-hemispheric connectivity within the basal ganglia (BG) nuclei in healthy and in unilateral 6-hydroxydopamine (6-OHDA) Parkinson diseaserat model in order to test the BG interhemispheric connectivity hypothesis. MATERIAL AND METHODS: The manganese-enhanced MRI (MEMRI) method with direct injection of manganese chloride into the entopeduncular (EP), substantia nigra (SN), and the Habenula nuclei in unilateral 6-OHDA (N = 22) and sham-operated (N = 16) rat groups was used. MEMRI measurements were applied before, 3, 24, and 48 hours post-manganese injection. Signal enhancements in T1-weighted images were compared between groups. RESULTS:Manganese injection into the EP nucleus resulted with bihemispheric signal enhancements in the habenular complex (Hab) at both groups with stronger enhancements in the 6-OHDA group. It also exhibited lower sensorimotor cortex signal enhancement in the 6-OHDArat group. SN manganese injection caused enhanced anteroventral thalamic and habenular nuclei signals in the 6-OHDArat group. Manganese habenula injection revealed enhanced interpeduncular (IP) and raphe nuclei signals of the 6-OHDArat group. CONCLUSION: Modulations in the effective intra- and interhemispheric BG connectivity in unilateral 6-OHDAParkinson's disease (PD) rat model support the BG interhemispheric connectivity hypothesis and suggest a linkage between the dopaminergic and serotonergic systems in PD, in line with clinical symptoms. (c) 2007 Wiley-Liss, Inc.
Authors: Assaf A Gilad; Piotr Walczak; Michael T McMahon; Hyon Bin Na; Jung Hee Lee; Kwangjin An; Taegwhan Hyeon; Peter C M van Zijl; Jeff W M Bulte Journal: Magn Reson Med Date: 2008-07 Impact factor: 4.668
Authors: Aditya N Bade; Biyun Zhou; JoEllyn McMillan; Prabagaran Narayanasamy; Ram Veerubhotla; Howard E Gendelman; Michael D Boska; Yutong Liu Journal: J Neurosci Methods Date: 2015-05-22 Impact factor: 2.390
Authors: Katherine E Olson; Aditya N Bade; Charles R Schutt; Jingdong Dong; Scott J Shandler; Michael D Boska; R Lee Mosley; Howard E Gendelman; Yutong Liu Journal: Neurotherapeutics Date: 2016-07 Impact factor: 7.620
Authors: Xin Yu; Seungsoo Chung; Der-Yow Chen; Shumin Wang; Stephen J Dodd; Judith R Walters; John T R Isaac; Alan P Koretsky Journal: Neuron Date: 2012-05-24 Impact factor: 17.173
Authors: Shane A Perrine; Farhad Ghoddoussi; Kirtan Desai; Robert J Kohler; Ajay T Eapen; Michael J Lisieski; Mariana Angoa-Perez; Donald M Kuhn; Kelly E Bosse; Alana C Conti; David Bissig; Bruce A Berkowitz Journal: NMR Biomed Date: 2015-09-28 Impact factor: 4.044
Authors: Dipanjan Pan; Angana Senpan; Shelton D Caruthers; Todd A Williams; Mike J Scott; Patrick J Gaffney; Samuel A Wickline; Gregory M Lanza Journal: Chem Commun (Camb) Date: 2009-04-22 Impact factor: 6.222