John A Kellum1. 1. Clinical Research, Investigation, and Systems Modeling of Acute Illness (CRISMA) Laboratory and the Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA. kellumja@upmc.edu
Abstract
BACKGROUND: Intensivists spend much of their time managing problems related to fluids, electrolytes, and blood pH. Recent advances in the understanding of acid-base physiology have resulted from the application of basic physical-chemical principles of aqueous solutions to blood plasma. All changes in blood pH, in health and in disease, occur through changes in three variables: carbon dioxide, relative electrolyte concentrations, and total weak acid concentrations. However, while this quantitative approach has enjoyed widespread use among researchers, clinicians are reluctant to employ it. Recent advances have brought a measure of parity between the newer and the older, descriptive approach to acid-base physiology. DATA SYNTHESIS: Case-based review of the literature. CONCLUSION: Both quantitative and traditional approaches can be easily combined to result in a powerful tool for bedside acid-base analysis.
BACKGROUND: Intensivists spend much of their time managing problems related to fluids, electrolytes, and blood pH. Recent advances in the understanding of acid-base physiology have resulted from the application of basic physical-chemical principles of aqueous solutions to blood plasma. All changes in blood pH, in health and in disease, occur through changes in three variables: carbon dioxide, relative electrolyte concentrations, and total weak acid concentrations. However, while this quantitative approach has enjoyed widespread use among researchers, clinicians are reluctant to employ it. Recent advances have brought a measure of parity between the newer and the older, descriptive approach to acid-base physiology. DATA SYNTHESIS: Case-based review of the literature. CONCLUSION: Both quantitative and traditional approaches can be easily combined to result in a powerful tool for bedside acid-base analysis.
Authors: Boris Jung; Thomas Rimmele; Charlotte Le Goff; Gérald Chanques; Philippe Corne; Olivier Jonquet; Laurent Muller; Jean-Yves Lefrant; Christophe Guervilly; Laurent Papazian; Bernard Allaouchiche; Samir Jaber Journal: Crit Care Date: 2011-10-13 Impact factor: 9.097
Authors: R Kishen; Patrick M Honoré; R Jacobs; O Joannes-Boyau; E De Waele; J De Regt; V Van Gorp; W Boer; Hd Spapen Journal: Int J Nephrol Renovasc Dis Date: 2014-06-04
Authors: Fernando G Zampieri; John A Kellum; Marcelo Park; Otavio T Ranzani; Hermes V Barbeiro; Heraldo P de Souza; Luiz Monteiro da Cruz Neto; Fabiano Pinheiro da Silva Journal: Crit Care Date: 2014-07-17 Impact factor: 9.097