| Literature DB >> 17892941 |
Javier A Ramírez1, Andrea C Bruttomesso, Flavia M Michelini, Sofía L Acebedo, Laura E Alché, Lydia R Galagovsky.
Abstract
In a previous work our group showed that some synthetic stigmastanes may play a role in immune-mediated inflammation. In this paper we report the syntheses of a series of new steroidal compounds derived from dehydroepiandrosterone and stigmasterol, and the evaluation of their in vitro inhibitory activity of the TNF-alpha production by macrophages. A preliminary qualitative structure-activity relationship was established.Entities:
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Year: 2007 PMID： 17892941 DOI： 10.1016/j.bmc.2007.09.012
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641