Literature DB >> 17892935

Heteroaryl beta-tetralin ureas as novel antagonists of human TRPV1.

Michele C Jetter1, Mark A Youngman, James J McNally, Mark E McDonnell, Sui-Po Zhang, Adrienne E Dubin, Nadia Nasser, Ellen E Codd, Christopher M Flores, Scott L Dax.   

Abstract

We report on a series of alpha-substituted-beta-tetralin-derived and related phenethyl-based isoquinolinyl and hydroxynaphthyl ureas as potent antagonists of the human TRPV1 receptor. The synthesis and Structure-activity relationships (SAR) of the series are described.

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Year:  2007        PMID： 17892935     DOI： 10.1016/j.bmcl.2007.09.036

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  3 in total

1.  2,2,2-Trifluoro-N-(isoquinolin-5-ylmeth-yl)acetamide.

Authors:  Alan R Kennedy; Abedawn I Khalaf; Colin J Suckling
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2009-12-12

2.  Design, Synthesis and Biological Evaluation of 1,4-Disubstituted-3,4-dihydroisoquinoline Compounds as New Tubulin Polymerization Inhibitors.

Authors:  Ling Zhang; Yunlong Song; Jingjing Huang; Jia Liu; Wenwen Zhu; Youjun Zhou; Jiaguo Lv; Canhui Zheng; Ju Zhu
Journal:  Int J Mol Sci       Date:  2015-05-05       Impact factor: 5.923

3.  Novel scaffolds for modulation of TRPV1 identified with pharmacophore modeling and virtual screening.

Authors:  Daria Goldmann; Peter Pakfeifer; Steffen Hering; Gerhard F Ecker
Journal:  Future Med Chem       Date:  2015       Impact factor: 4.767
  3 in total

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