| Literature DB >> 17891485 |
Bernd Frank1, Sushila H Rigas, Justo Lorenzo Bermejo, Miriam Wiestler, Kerstin Wagner, Kari Hemminki, Malcolm W Reed, Christian Sutter, Barbara Wappenschmidt, Sabapathy P Balasubramanian, Alfons Meindl, Marion Kiechle, Peter Bugert, Rita K Schmutzler, Claus R Bartram, Christina Justenhoven, Yon-Dschun Ko, Thomas Brüning, Hiltrud Brauch, Ute Hamann, Paul P D Pharoah, Alison M Dunning, Karen A Pooley, Douglas F Easton, Angela Cox, Barbara Burwinkel.
Abstract
A recent study on an Asian population reported a six-nucleotide insertion-deletion polymorphism (-652 6N del) in the CASP8 promoter region to be strongly associated with a decreased risk of multiple types of cancer, including breast cancer (BC). Here, we investigate the effect of this deletion in four independent large European BC case-control studies, including data from a total of 7,753 cases and 7,921 controls. The combined per allele odds ratio (OR) was 0.97 (95% confidence interval (CI), 95% CI = 0.93-1.02). The present result indicates that the CASP8 -652 6N del variant has no significant effect on BC risk in Europeans.Entities:
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Year: 2007 PMID： 17891485 DOI： 10.1007/s10549-007-9752-z
Source DB: PubMed Journal: Breast Cancer Res Treat ISSN： 0167-6806 Impact factor: 4.872